Spatial Mapping of Hematopoietic Clones in Human Bone Marrow

Clonal hematopoiesis (CH) is the expansion of somatically mutated cells in the hematopoietic compartment of individuals without hematopoietic dysfunction. Large CH clones (i.e., >2% variant allele fraction) predispose to hematologic malignancy, but CH is detected at lower levels in nearly all mid...

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Veröffentlicht in:	Blood cancer discovery 2024-05, Vol.5 (3), p.153-163
Hauptverfasser:	Young, Andrew L, Davis, Hannah C, Cox, Maggie J, Parsons, Tyler M, Burkart, Samantha C, Bender, Diane E, Sun, Lulu, Oh, Stephen T, Challen, Grant A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow - pathology Clonal Hematopoiesis - genetics Clone Cells Hematological Cancers Hematopoietic Stem Cells - pathology Humans Mutation Polycythemia Vera - diagnosis Polycythemia Vera - genetics Polycythemia Vera - pathology Research Brief Single Cell Technologies Tumor Heterogeneity
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