GM3 synthase deficiency increases brain glucose metabolism in mice

GM3 synthase (GM3S) deficiency is a rare neurodevelopmental disorder caused by an inability to synthesize gangliosides, for which there is currently no treatment. Gangliosides are brain-enriched, plasma membrane glycosphingolipids with poorly understood biological functions related to cell adhesion,...

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Veröffentlicht in:	Molecular genetics and metabolism 2022-12, Vol.137 (4), p.342-348
Hauptverfasser:	Bharathi, Sivakama S., Zhang, Bob B., Paul, Eli, Zhang, Yuxun, Schmidt, Alexandra V., Fowler, Benjamin, Wu, Yijen, Tiemeyer, Michael, Inamori, Kei-ichiro, Inokuchi, Jin-ichi, Goetzman, Eric S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain - metabolism G(M3) Ganglioside - metabolism Ganglioside Glucose - metabolism GM3 Mice Mice, Knockout Mitochondria Pyruvic Acid Seizure Seizures - genetics Sialyltransferases - genetics Sialyltransferases - metabolism
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