The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters

Background/Aims: This study is aimed to compare the effects of nutrition which has been enriched with different amounts of gluten to gluten-free diets on weight gain, diabetogenic state, hematological, and biochemical parameters. Materials and Methods: A total of 40 newly weaned male Wistar albino r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Turkish Journal of Gastroenterology 2024-03, Vol.35 (3), p.178-185
Hauptverfasser: Bektas, Atilla, Ulusoy, Meltem, Ozsari, Levent, Ozel, Ahmet Melih
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 185
container_issue 3
container_start_page 178
container_title The Turkish Journal of Gastroenterology
container_volume 35
creator Bektas, Atilla
Ulusoy, Meltem
Ozsari, Levent
Ozel, Ahmet Melih
description Background/Aims: This study is aimed to compare the effects of nutrition which has been enriched with different amounts of gluten to gluten-free diets on weight gain, diabetogenic state, hematological, and biochemical parameters. Materials and Methods: A total of 40 newly weaned male Wistar albino rats used in the study were randomized into 4 different groups based on the gluten rations they were given. Following 12 weeks of diet they were killed and intracardiac blood samples were collected. Groups were identified as group 1 (n = 10): control group; normal rat ration containing wheat, group 2 (n = 10): gluten-free diet, group 3 (n = 10): ration containing medium level of gluten (normal rat diet + 6% vital gluten) and group 4 (n = 10): ration containing high level of gluten (normal rat diet + 12% vital gluten). Results: In groups 3 and 4, high-density lipoprotein was found to be higher than the other 2groups. However, when group 2 results were compared to the other groups; the highest T3, T4, creatinine and B12 levels and the lowest gluten-specific IgE level were observed. alanine aminotransferase and aspartate aminotransferase levels were found to be higher in group 1 compared to the other 3 groups. No statistically significant difference was detected between the groups in terms of other parameters. Conclusion: This study provides evidence that a gluten-containing diet does not cause weight gain, has no diabetogenic effect, and also does not adversely affect general health in relation to hematological, biochemical, and various endocrinological parameters. Keywords: Gluten, gluten-free diet, weight gain, diabetogenic, glycemia, thyroid functions
doi_str_mv 10.5152/tjg.2024.23210
format Article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11059451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A786321682</galeid><doaj_id>oai_doaj_org_article_9861cb6cb9ed47358055da733c8870e3</doaj_id><sourcerecordid>A786321682</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-cc3b4d04cf9550e5aae82101ce3ec9a6632492dff7faeed0d5076d550dfb26383</originalsourceid><addsrcrecordid>eNqNksFvFCEUxidGE9fq1TOJFw-d9QEDw5xMbdZtkyZ6qHokLDxm2cxAZWZN_O9lutWk0YPhQHj83gcffFX1msJaUMHezYd-zYA1a8YZhSfVitFG1UJC-7RaUQ5QN12jnlcvpukAwBWVbFWF2z2Sjfdo54kkT7bDccZIUiTfMPT7mWxNiOfkCkczpyH1wZrhnHwIye5xPC1MdOSrySEdJ7KJLtkc4m-UfDbZjDhjnl5Wz7wZJnz1MJ9VXz5ubi-v6ptP2-vLi5vaNorPtbV81zhorO-EABTGoCp2qEWOtjNSctZ0zHnfeoPowAlopSuo8zsmueJn1fVJ1yVz0Hc5jCb_1MkEfV9Iudcmz8EOqDslqd1Ju-vQNS0XCoRwpuXcKtUC8qL1_qR1d9yN6CzGOZvhkejjnRj2uk8_NKUgukbQovD2QSGn70ecZj2GyeIwmIjlwTSHjgEFUAv65oT2ptwtRJ-KpF1wfdGq4ptKxQq1_gdVhlv-I0X0odRLQydBUib-v-GvE2xO05TR__FLQS9J0yVpekmavk8a_wW3n8YA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3092010081</pqid></control><display><type>article</type><title>The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Bektas, Atilla ; Ulusoy, Meltem ; Ozsari, Levent ; Ozel, Ahmet Melih</creator><creatorcontrib>Bektas, Atilla ; Ulusoy, Meltem ; Ozsari, Levent ; Ozel, Ahmet Melih ; Department of Gastroenterology, Anadolu Medical Center Hospital, İstanbul, Turkey ; Department of Gastroenterology, Private Ankara Surgery Medical Center, Ankara, Turkey ; Department of Endocrinology and Metabolic Diseases, Sultan 2. Abdulhamid Khan Educational and Research Hospital, İstanbul, Turkey ; Division of Applied Biology, Department of Biology, Hacettepe University, Ankara, Turkey</creatorcontrib><description>Background/Aims: This study is aimed to compare the effects of nutrition which has been enriched with different amounts of gluten to gluten-free diets on weight gain, diabetogenic state, hematological, and biochemical parameters. Materials and Methods: A total of 40 newly weaned male Wistar albino rats used in the study were randomized into 4 different groups based on the gluten rations they were given. Following 12 weeks of diet they were killed and intracardiac blood samples were collected. Groups were identified as group 1 (n = 10): control group; normal rat ration containing wheat, group 2 (n = 10): gluten-free diet, group 3 (n = 10): ration containing medium level of gluten (normal rat diet + 6% vital gluten) and group 4 (n = 10): ration containing high level of gluten (normal rat diet + 12% vital gluten). Results: In groups 3 and 4, high-density lipoprotein was found to be higher than the other 2groups. However, when group 2 results were compared to the other groups; the highest T3, T4, creatinine and B12 levels and the lowest gluten-specific IgE level were observed. alanine aminotransferase and aspartate aminotransferase levels were found to be higher in group 1 compared to the other 3 groups. No statistically significant difference was detected between the groups in terms of other parameters. Conclusion: This study provides evidence that a gluten-containing diet does not cause weight gain, has no diabetogenic effect, and also does not adversely affect general health in relation to hematological, biochemical, and various endocrinological parameters. Keywords: Gluten, gluten-free diet, weight gain, diabetogenic, glycemia, thyroid functions</description><identifier>ISSN: 1300-4948</identifier><identifier>ISSN: 2148-5607</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.5152/tjg.2024.23210</identifier><language>eng</language><publisher>AVES</publisher><subject>Aspartate ; Diabetes ; Gastrointestinal Tract ; Gluten ; Gluten-free diet ; Health aspects ; Original ; Risk factors ; Thyroid diseases ; Thyroid gland ; Type 2 diabetes ; Weight gain</subject><ispartof>The Turkish Journal of Gastroenterology, 2024-03, Vol.35 (3), p.178-185</ispartof><rights>COPYRIGHT 2024 AVES</rights><rights>2024 authors 2024 authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059451/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059451/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Bektas, Atilla</creatorcontrib><creatorcontrib>Ulusoy, Meltem</creatorcontrib><creatorcontrib>Ozsari, Levent</creatorcontrib><creatorcontrib>Ozel, Ahmet Melih</creatorcontrib><creatorcontrib>Department of Gastroenterology, Anadolu Medical Center Hospital, İstanbul, Turkey</creatorcontrib><creatorcontrib>Department of Gastroenterology, Private Ankara Surgery Medical Center, Ankara, Turkey</creatorcontrib><creatorcontrib>Department of Endocrinology and Metabolic Diseases, Sultan 2. Abdulhamid Khan Educational and Research Hospital, İstanbul, Turkey</creatorcontrib><creatorcontrib>Division of Applied Biology, Department of Biology, Hacettepe University, Ankara, Turkey</creatorcontrib><title>The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters</title><title>The Turkish Journal of Gastroenterology</title><description>Background/Aims: This study is aimed to compare the effects of nutrition which has been enriched with different amounts of gluten to gluten-free diets on weight gain, diabetogenic state, hematological, and biochemical parameters. Materials and Methods: A total of 40 newly weaned male Wistar albino rats used in the study were randomized into 4 different groups based on the gluten rations they were given. Following 12 weeks of diet they were killed and intracardiac blood samples were collected. Groups were identified as group 1 (n = 10): control group; normal rat ration containing wheat, group 2 (n = 10): gluten-free diet, group 3 (n = 10): ration containing medium level of gluten (normal rat diet + 6% vital gluten) and group 4 (n = 10): ration containing high level of gluten (normal rat diet + 12% vital gluten). Results: In groups 3 and 4, high-density lipoprotein was found to be higher than the other 2groups. However, when group 2 results were compared to the other groups; the highest T3, T4, creatinine and B12 levels and the lowest gluten-specific IgE level were observed. alanine aminotransferase and aspartate aminotransferase levels were found to be higher in group 1 compared to the other 3 groups. No statistically significant difference was detected between the groups in terms of other parameters. Conclusion: This study provides evidence that a gluten-containing diet does not cause weight gain, has no diabetogenic effect, and also does not adversely affect general health in relation to hematological, biochemical, and various endocrinological parameters. Keywords: Gluten, gluten-free diet, weight gain, diabetogenic, glycemia, thyroid functions</description><subject>Aspartate</subject><subject>Diabetes</subject><subject>Gastrointestinal Tract</subject><subject>Gluten</subject><subject>Gluten-free diet</subject><subject>Health aspects</subject><subject>Original</subject><subject>Risk factors</subject><subject>Thyroid diseases</subject><subject>Thyroid gland</subject><subject>Type 2 diabetes</subject><subject>Weight gain</subject><issn>1300-4948</issn><issn>2148-5607</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqNksFvFCEUxidGE9fq1TOJFw-d9QEDw5xMbdZtkyZ6qHokLDxm2cxAZWZN_O9lutWk0YPhQHj83gcffFX1msJaUMHezYd-zYA1a8YZhSfVitFG1UJC-7RaUQ5QN12jnlcvpukAwBWVbFWF2z2Sjfdo54kkT7bDccZIUiTfMPT7mWxNiOfkCkczpyH1wZrhnHwIye5xPC1MdOSrySEdJ7KJLtkc4m-UfDbZjDhjnl5Wz7wZJnz1MJ9VXz5ubi-v6ptP2-vLi5vaNorPtbV81zhorO-EABTGoCp2qEWOtjNSctZ0zHnfeoPowAlopSuo8zsmueJn1fVJ1yVz0Hc5jCb_1MkEfV9Iudcmz8EOqDslqd1Ju-vQNS0XCoRwpuXcKtUC8qL1_qR1d9yN6CzGOZvhkejjnRj2uk8_NKUgukbQovD2QSGn70ecZj2GyeIwmIjlwTSHjgEFUAv65oT2ptwtRJ-KpF1wfdGq4ptKxQq1_gdVhlv-I0X0odRLQydBUib-v-GvE2xO05TR__FLQS9J0yVpekmavk8a_wW3n8YA</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Bektas, Atilla</creator><creator>Ulusoy, Meltem</creator><creator>Ozsari, Levent</creator><creator>Ozel, Ahmet Melih</creator><general>AVES</general><general>Turkish Society of Gastroenterology</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240301</creationdate><title>The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters</title><author>Bektas, Atilla ; Ulusoy, Meltem ; Ozsari, Levent ; Ozel, Ahmet Melih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-cc3b4d04cf9550e5aae82101ce3ec9a6632492dff7faeed0d5076d550dfb26383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aspartate</topic><topic>Diabetes</topic><topic>Gastrointestinal Tract</topic><topic>Gluten</topic><topic>Gluten-free diet</topic><topic>Health aspects</topic><topic>Original</topic><topic>Risk factors</topic><topic>Thyroid diseases</topic><topic>Thyroid gland</topic><topic>Type 2 diabetes</topic><topic>Weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bektas, Atilla</creatorcontrib><creatorcontrib>Ulusoy, Meltem</creatorcontrib><creatorcontrib>Ozsari, Levent</creatorcontrib><creatorcontrib>Ozel, Ahmet Melih</creatorcontrib><creatorcontrib>Department of Gastroenterology, Anadolu Medical Center Hospital, İstanbul, Turkey</creatorcontrib><creatorcontrib>Department of Gastroenterology, Private Ankara Surgery Medical Center, Ankara, Turkey</creatorcontrib><creatorcontrib>Department of Endocrinology and Metabolic Diseases, Sultan 2. Abdulhamid Khan Educational and Research Hospital, İstanbul, Turkey</creatorcontrib><creatorcontrib>Division of Applied Biology, Department of Biology, Hacettepe University, Ankara, Turkey</creatorcontrib><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>The Turkish Journal of Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bektas, Atilla</au><au>Ulusoy, Meltem</au><au>Ozsari, Levent</au><au>Ozel, Ahmet Melih</au><aucorp>Department of Gastroenterology, Anadolu Medical Center Hospital, İstanbul, Turkey</aucorp><aucorp>Department of Gastroenterology, Private Ankara Surgery Medical Center, Ankara, Turkey</aucorp><aucorp>Department of Endocrinology and Metabolic Diseases, Sultan 2. Abdulhamid Khan Educational and Research Hospital, İstanbul, Turkey</aucorp><aucorp>Division of Applied Biology, Department of Biology, Hacettepe University, Ankara, Turkey</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters</atitle><jtitle>The Turkish Journal of Gastroenterology</jtitle><date>2024-03-01</date><risdate>2024</risdate><volume>35</volume><issue>3</issue><spage>178</spage><epage>185</epage><pages>178-185</pages><issn>1300-4948</issn><issn>2148-5607</issn><eissn>2148-5607</eissn><abstract>Background/Aims: This study is aimed to compare the effects of nutrition which has been enriched with different amounts of gluten to gluten-free diets on weight gain, diabetogenic state, hematological, and biochemical parameters. Materials and Methods: A total of 40 newly weaned male Wistar albino rats used in the study were randomized into 4 different groups based on the gluten rations they were given. Following 12 weeks of diet they were killed and intracardiac blood samples were collected. Groups were identified as group 1 (n = 10): control group; normal rat ration containing wheat, group 2 (n = 10): gluten-free diet, group 3 (n = 10): ration containing medium level of gluten (normal rat diet + 6% vital gluten) and group 4 (n = 10): ration containing high level of gluten (normal rat diet + 12% vital gluten). Results: In groups 3 and 4, high-density lipoprotein was found to be higher than the other 2groups. However, when group 2 results were compared to the other groups; the highest T3, T4, creatinine and B12 levels and the lowest gluten-specific IgE level were observed. alanine aminotransferase and aspartate aminotransferase levels were found to be higher in group 1 compared to the other 3 groups. No statistically significant difference was detected between the groups in terms of other parameters. Conclusion: This study provides evidence that a gluten-containing diet does not cause weight gain, has no diabetogenic effect, and also does not adversely affect general health in relation to hematological, biochemical, and various endocrinological parameters. Keywords: Gluten, gluten-free diet, weight gain, diabetogenic, glycemia, thyroid functions</abstract><pub>AVES</pub><doi>10.5152/tjg.2024.23210</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1300-4948
ispartof The Turkish Journal of Gastroenterology, 2024-03, Vol.35 (3), p.178-185
issn 1300-4948
2148-5607
2148-5607
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11059451
source DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Aspartate
Diabetes
Gastrointestinal Tract
Gluten
Gluten-free diet
Health aspects
Original
Risk factors
Thyroid diseases
Thyroid gland
Type 2 diabetes
Weight gain
title The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A58%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effects%20of%20Gluten%20on%20Weight%20Gain,%20Hematological,%20Biochemical,%20and%20Various%20Endocrinological%20Parameters&rft.jtitle=The%20Turkish%20Journal%20of%20Gastroenterology&rft.au=Bektas,%20Atilla&rft.aucorp=Department%20of%20Gastroenterology,%20Anadolu%20Medical%20Center%20Hospital,%20%C4%B0stanbul,%20Turkey&rft.date=2024-03-01&rft.volume=35&rft.issue=3&rft.spage=178&rft.epage=185&rft.pages=178-185&rft.issn=1300-4948&rft.eissn=2148-5607&rft_id=info:doi/10.5152/tjg.2024.23210&rft_dat=%3Cgale_doaj_%3EA786321682%3C/gale_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3092010081&rft_id=info:pmid/&rft_galeid=A786321682&rft_doaj_id=oai_doaj_org_article_9861cb6cb9ed47358055da733c8870e3&rfr_iscdi=true