Tumor mutational load is prognostic for progression to therapy among high-count monoclonal B-cell lymphocytosis

•Tumor mutational load is a strong prognostic factor for progression to therapy among individuals with HCMBL, independent of CLL-IPI.•Accounting for both CLL-IPI and tumor mutational load, we identified individuals with HCMBL who have a worse prognosis than patients at low risk with CLL. [Display om...

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Veröffentlicht in:	Blood advances 2024-05, Vol.8 (9), p.2118-2129
Hauptverfasser:	Kleinstern, Geffen, Boddicker, Nicholas J., O’Brien, Daniel R., Allmer, Cristine, Rabe, Kari G., Norman, Aaron D., Griffin, Rosalie, Yan, Huihuang, Ma, Tao, Call, Timothy G., Bruins, Laura, Brown, Sochilt, Bonolo de Campos, Cecilia, Hanson, Curtis A., Leis, Jose F., Ding, Wei, Vachon, Celine M., Kay, Neil E., Oakes, Christopher C., Parker, Alexander S., Brander, Danielle M., Weinberg, J. Brice, Furman, Richard R., Shanafelt, Tait D., Cerhan, James R., Parikh, Sameer A., Braggio, Esteban, Slager, Susan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over B-Lymphocytes - metabolism B-Lymphocytes - pathology Clinical Trials and Observations Disease Progression Female Humans Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - therapy Lymphocyte Count Lymphocytosis - diagnosis Lymphocytosis - genetics Lymphocytosis - therapy Male Middle Aged Mutation Prognosis
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