Selective Targeting of Regulated Rhabdomyosarcoma Cells by Trinuclear Ruthenium(II)–Arene Complexes

The use of benzimidazole-based trinuclear ruthenium(II)–arene complexes (1–3) to selectively target the rare cancer rhabdomyosarcoma is reported. Preliminary cytotoxic evaluations of the ruthenium complexes in an eight-cancer cell line panel revealed enhanced, selective cytotoxicity toward rhabdomy...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-04, Vol.67 (8), p.6673-6686
Hauptverfasser:	Welsh, Athi, Serala, Karabo, Prince, Sharon, Smith, Gregory S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Autophagy - drug effects Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology DNA Damage - drug effects Drug Screening Assays, Antitumor Humans Rhabdomyosarcoma - drug therapy Rhabdomyosarcoma - pathology Ruthenium - chemistry Ruthenium - pharmacology Structure-Activity Relationship
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