Role of Geminin as a Tool for Augmenting Accurate Diagnosis of Cervical Neoplasia
To determine the role of geminin as a tool for differentiating various types of cervical intraepithelial neoplasia (CIN) and cervical carcinoma (CC). Seventy women newly diagnosed with CIN or CC undergoing cervical biopsy were included; their clinical profile, human papilloma virus (HPV) positivity,...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-03, Vol.16 (3), p.e56864-e56864 |
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| creator | Bagde, Nilajkumar D Bagde, Madhuri N Agrawal, Sarita Nayak, Prasanta Negi, Sanjay Singh Rajbhar, Sarita Hussain, Nighat |
| description | To determine the role of geminin as a tool for differentiating various types of cervical intraepithelial neoplasia (CIN) and cervical carcinoma (CC).
Seventy women newly diagnosed with CIN or CC undergoing cervical biopsy were included; their clinical profile, human papilloma virus (HPV) positivity, and colposcopy findings were noted, and biopsy tissue was analyzed for geminin content.
On geminin immunohistochemistry, 100% of women with CIN3 and 96.29% of women with CC had geminin two plus or more. When analyzed as ordinal variables, there was a significant correlation (spearman's rho 0.35, p 0.01) between geminin and biopsy results (CIN1, CIN2, CIN3, and CC).
Screening tests for cervical cancer, like conventional pap smears, liquid-based pap smears, and triaging with HPV, have limitations. It is important to be able to differentiate between high-grade lesions, invasive cancer, and low-grade lesions. The detection of geminin in these cells may aid in the confirmation of the diagnosis and ensure adequate treatment. Cervical intraepithelial lesions and carcinoma cervix demonstrated a correlation between increased geminin expression in CIN1 vs. CC and CIN2 vs. CC. Geminin may be a potential surrogate marker for higher-grade cervical lesions, and further research is needed to corroborate evidence in this direction. |
| doi_str_mv | 10.7759/cureus.56864 |
| format | Article |
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Seventy women newly diagnosed with CIN or CC undergoing cervical biopsy were included; their clinical profile, human papilloma virus (HPV) positivity, and colposcopy findings were noted, and biopsy tissue was analyzed for geminin content.
On geminin immunohistochemistry, 100% of women with CIN3 and 96.29% of women with CC had geminin two plus or more. When analyzed as ordinal variables, there was a significant correlation (spearman's rho 0.35, p 0.01) between geminin and biopsy results (CIN1, CIN2, CIN3, and CC).
Screening tests for cervical cancer, like conventional pap smears, liquid-based pap smears, and triaging with HPV, have limitations. It is important to be able to differentiate between high-grade lesions, invasive cancer, and low-grade lesions. The detection of geminin in these cells may aid in the confirmation of the diagnosis and ensure adequate treatment. Cervical intraepithelial lesions and carcinoma cervix demonstrated a correlation between increased geminin expression in CIN1 vs. CC and CIN2 vs. CC. Geminin may be a potential surrogate marker for higher-grade cervical lesions, and further research is needed to corroborate evidence in this direction.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.56864</identifier><identifier>PMID: 38659554</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Age ; Biopsy ; Body mass index ; Cancer ; Cell division ; Cervical cancer ; Cervix ; Chromosomes ; Deoxyribonucleic acid ; DNA ; Family/General Practice ; Gynecology ; Human papillomavirus ; Illiteracy ; Licenses ; Marriage ; Medical diagnosis ; Obstetrics/Gynecology ; Oncology ; Vagina ; Womens health</subject><ispartof>Curēus (Palo Alto, CA), 2024-03, Vol.16 (3), p.e56864-e56864</ispartof><rights>Copyright © 2024, Bagde et al.</rights><rights>Copyright © 2024, Bagde et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, Bagde et al. 2024 Bagde et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-54e3ca399549ccc14177cc65fee5272ce06469e6e4193937e8d68fcd0a2da0053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11040424/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11040424/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38659554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bagde, Nilajkumar D</creatorcontrib><creatorcontrib>Bagde, Madhuri N</creatorcontrib><creatorcontrib>Agrawal, Sarita</creatorcontrib><creatorcontrib>Nayak, Prasanta</creatorcontrib><creatorcontrib>Negi, Sanjay Singh</creatorcontrib><creatorcontrib>Rajbhar, Sarita</creatorcontrib><creatorcontrib>Hussain, Nighat</creatorcontrib><title>Role of Geminin as a Tool for Augmenting Accurate Diagnosis of Cervical Neoplasia</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>To determine the role of geminin as a tool for differentiating various types of cervical intraepithelial neoplasia (CIN) and cervical carcinoma (CC).
Seventy women newly diagnosed with CIN or CC undergoing cervical biopsy were included; their clinical profile, human papilloma virus (HPV) positivity, and colposcopy findings were noted, and biopsy tissue was analyzed for geminin content.
On geminin immunohistochemistry, 100% of women with CIN3 and 96.29% of women with CC had geminin two plus or more. When analyzed as ordinal variables, there was a significant correlation (spearman's rho 0.35, p 0.01) between geminin and biopsy results (CIN1, CIN2, CIN3, and CC).
Screening tests for cervical cancer, like conventional pap smears, liquid-based pap smears, and triaging with HPV, have limitations. It is important to be able to differentiate between high-grade lesions, invasive cancer, and low-grade lesions. The detection of geminin in these cells may aid in the confirmation of the diagnosis and ensure adequate treatment. Cervical intraepithelial lesions and carcinoma cervix demonstrated a correlation between increased geminin expression in CIN1 vs. CC and CIN2 vs. CC. Geminin may be a potential surrogate marker for higher-grade cervical lesions, and further research is needed to corroborate evidence in this direction.</description><subject>Age</subject><subject>Biopsy</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Cell division</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Chromosomes</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Family/General Practice</subject><subject>Gynecology</subject><subject>Human papillomavirus</subject><subject>Illiteracy</subject><subject>Licenses</subject><subject>Marriage</subject><subject>Medical diagnosis</subject><subject>Obstetrics/Gynecology</subject><subject>Oncology</subject><subject>Vagina</subject><subject>Womens health</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1LAzEQxYMoKtqbZwl48WB1svnanKTUTxBF0XOI6WyN7G5q0hX8793aKuppBuY3b97wCNljcKy1NCe-S9jlY6lKJdbIdsFUOSxZKdZ_9VtkkPMrADDQBWjYJFu8VNJIKbbJ_UOskcaKXmIT2tBSl6mjjzHWtIqJjrppg-08tFM68v0xN0d6Fty0jTnkxdoY03vwrqa3GGe1y8Htko3K1RkHq7pDni7OH8dXw5u7y-vx6GboOcB8KAVy77gxUhjvPRNMa--VrBBloQuPoIQyqFAwww3XWE5UWfkJuGLiACTfIadL3Vn33ODE9zaTq-0shcalDxtdsH8nbXix0_huGQMBohC9wuFKIcW3DvPcNiF7rGvXYuyy5SCUZFJy3aMH_9DX2KW2_29BmRKM4tBTR0vKp5hzwurHDQO7yMsu87JfefX4_u8PfuDvdPgnMtuRUg</recordid><startdate>20240325</startdate><enddate>20240325</enddate><creator>Bagde, Nilajkumar D</creator><creator>Bagde, Madhuri N</creator><creator>Agrawal, Sarita</creator><creator>Nayak, Prasanta</creator><creator>Negi, Sanjay Singh</creator><creator>Rajbhar, Sarita</creator><creator>Hussain, Nighat</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240325</creationdate><title>Role of Geminin as a Tool for Augmenting Accurate Diagnosis of Cervical Neoplasia</title><author>Bagde, Nilajkumar D ; Bagde, Madhuri N ; Agrawal, Sarita ; Nayak, Prasanta ; Negi, Sanjay Singh ; Rajbhar, Sarita ; Hussain, Nighat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-54e3ca399549ccc14177cc65fee5272ce06469e6e4193937e8d68fcd0a2da0053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Biopsy</topic><topic>Body mass index</topic><topic>Cancer</topic><topic>Cell division</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Chromosomes</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Family/General Practice</topic><topic>Gynecology</topic><topic>Human papillomavirus</topic><topic>Illiteracy</topic><topic>Licenses</topic><topic>Marriage</topic><topic>Medical diagnosis</topic><topic>Obstetrics/Gynecology</topic><topic>Oncology</topic><topic>Vagina</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagde, Nilajkumar D</creatorcontrib><creatorcontrib>Bagde, Madhuri N</creatorcontrib><creatorcontrib>Agrawal, Sarita</creatorcontrib><creatorcontrib>Nayak, Prasanta</creatorcontrib><creatorcontrib>Negi, Sanjay Singh</creatorcontrib><creatorcontrib>Rajbhar, Sarita</creatorcontrib><creatorcontrib>Hussain, Nighat</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagde, Nilajkumar D</au><au>Bagde, Madhuri N</au><au>Agrawal, Sarita</au><au>Nayak, Prasanta</au><au>Negi, Sanjay Singh</au><au>Rajbhar, Sarita</au><au>Hussain, Nighat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Geminin as a Tool for Augmenting Accurate Diagnosis of Cervical Neoplasia</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-03-25</date><risdate>2024</risdate><volume>16</volume><issue>3</issue><spage>e56864</spage><epage>e56864</epage><pages>e56864-e56864</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>To determine the role of geminin as a tool for differentiating various types of cervical intraepithelial neoplasia (CIN) and cervical carcinoma (CC).
Seventy women newly diagnosed with CIN or CC undergoing cervical biopsy were included; their clinical profile, human papilloma virus (HPV) positivity, and colposcopy findings were noted, and biopsy tissue was analyzed for geminin content.
On geminin immunohistochemistry, 100% of women with CIN3 and 96.29% of women with CC had geminin two plus or more. When analyzed as ordinal variables, there was a significant correlation (spearman's rho 0.35, p 0.01) between geminin and biopsy results (CIN1, CIN2, CIN3, and CC).
Screening tests for cervical cancer, like conventional pap smears, liquid-based pap smears, and triaging with HPV, have limitations. It is important to be able to differentiate between high-grade lesions, invasive cancer, and low-grade lesions. The detection of geminin in these cells may aid in the confirmation of the diagnosis and ensure adequate treatment. Cervical intraepithelial lesions and carcinoma cervix demonstrated a correlation between increased geminin expression in CIN1 vs. CC and CIN2 vs. CC. Geminin may be a potential surrogate marker for higher-grade cervical lesions, and further research is needed to corroborate evidence in this direction.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38659554</pmid><doi>10.7759/cureus.56864</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age Biopsy Body mass index Cancer Cell division Cervical cancer Cervix Chromosomes Deoxyribonucleic acid DNA Family/General Practice Gynecology Human papillomavirus Illiteracy Licenses Marriage Medical diagnosis Obstetrics/Gynecology Oncology Vagina Womens health |
| title | Role of Geminin as a Tool for Augmenting Accurate Diagnosis of Cervical Neoplasia |
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