Mimicking kidney flow shear efficiently induces aggregation of LECT2, a protein involved in renal amyloidosis

Aggregation of leukocyte cell-derived chemotaxin 2 (LECT2) causes ALECT2, a systemic amyloidosis that affects the kidney and liver. Previous studies established that LECT2 fibrillogenesis is accelerated by the loss of its bound zinc ion and stirring/shaking. These forms of agitation create heterogen...

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Veröffentlicht in:	The Journal of biological chemistry 2024-05, Vol.300 (5), p.107231-107231, Article 107231
Hauptverfasser:	Ha, Jeung-Hoi, Xu, Yikang, Sekhon, Harsimranjit, Zhao, Wenhan, Wilkens, Stephan, Ren, Dacheng, Loh, Stewart N.
Format:	Artikel
Sprache:	eng
Schlagworte:	ALECT2 heparan sulfate heparin hydrodynamic shear microfluidic device protein misfolding systemic amyloidosis
Online-Zugang:	Volltext
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