Deficient expression of class-I HLA in some cases of acute leukemia
Leukemic cells from the blood and marrow of 25 cases of newly diagnosed acute leukemia were presented as target cells to alloreactive effector cells from unrelated normal donors in cell-mediated cytotoxicity assays. In three cases the leukemic targets were poorly killed relative to nonleukemic, HLA-...
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| Veröffentlicht in: | Cancer Immunology Immunotherapy 1984-01, Vol.18 (2), p.91-100 |
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| container_title | Cancer Immunology Immunotherapy |
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| creator | ELKINS, W. L PICKARD, A PIERSON, G. R |
| description | Leukemic cells from the blood and marrow of 25 cases of newly diagnosed acute leukemia were presented as target cells to alloreactive effector cells from unrelated normal donors in cell-mediated cytotoxicity assays. In three cases the leukemic targets were poorly killed relative to nonleukemic, HLA-identical target cells. The poor killing of the leukemic cells from one of these cases was shown by competitive inhibition to be due to deficient expression of normal class-I HLA antigens rather than resistance to lysis. Furthermore, the leukemic cells from these three patients were also deficient in binding monoclonal antibodies to nonpolymorphic determinants of class-I HLA and B2 microglobulin. Two additional cases were identified as having a less extensive deficit of HLA, and may be representative of a group with relatively subtle changes in these cell surface antigens. The possible significance of reduced expression of HLA in leukemic progression and in susceptibility to graft-vs-leukemia reactions after bone marrow transplantation is discussed. |
| doi_str_mv | 10.1007/BF00205741 |
| format | Article |
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Two additional cases were identified as having a less extensive deficit of HLA, and may be representative of a group with relatively subtle changes in these cell surface antigens. The possible significance of reduced expression of HLA in leukemic progression and in susceptibility to graft-vs-leukemia reactions after bone marrow transplantation is discussed.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/BF00205741</identifier><identifier>PMID: 6239685</identifier><identifier>CODEN: CIIMDN</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acute Disease ; Biological and medical sciences ; Bone Marrow - immunology ; Cells, Cultured ; Child ; Cytotoxicity, Immunologic ; Fluorescent Antibody Technique ; Hematologic and hematopoietic diseases ; HLA Antigens - analysis ; Humans ; Leukemia - immunology ; Leukemia - pathology ; Leukemia, Lymphoid - immunology ; Leukemia, Myeloid, Acute - immunology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocyte Culture Test, Mixed ; Medical sciences ; Original</subject><ispartof>Cancer Immunology Immunotherapy, 1984-01, Vol.18 (2), p.91-100</ispartof><rights>1985 INIST-CNRS</rights><rights>Springer-Verlag 1984</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-a4cb89af9444672311c2d39d3406a566dcdb3b61db07f98bf46c104411b2edf73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11039252/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11039252/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9058521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6239685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ELKINS, W. L</creatorcontrib><creatorcontrib>PICKARD, A</creatorcontrib><creatorcontrib>PIERSON, G. R</creatorcontrib><title>Deficient expression of class-I HLA in some cases of acute leukemia</title><title>Cancer Immunology Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><description>Leukemic cells from the blood and marrow of 25 cases of newly diagnosed acute leukemia were presented as target cells to alloreactive effector cells from unrelated normal donors in cell-mediated cytotoxicity assays. In three cases the leukemic targets were poorly killed relative to nonleukemic, HLA-identical target cells. The poor killing of the leukemic cells from one of these cases was shown by competitive inhibition to be due to deficient expression of normal class-I HLA antigens rather than resistance to lysis. Furthermore, the leukemic cells from these three patients were also deficient in binding monoclonal antibodies to nonpolymorphic determinants of class-I HLA and B2 microglobulin. Two additional cases were identified as having a less extensive deficit of HLA, and may be representative of a group with relatively subtle changes in these cell surface antigens. The possible significance of reduced expression of HLA in leukemic progression and in susceptibility to graft-vs-leukemia reactions after bone marrow transplantation is discussed.</description><subject>Acute Disease</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - immunology</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Cytotoxicity, Immunologic</subject><subject>Fluorescent Antibody Technique</subject><subject>Hematologic and hematopoietic diseases</subject><subject>HLA Antigens - analysis</subject><subject>Humans</subject><subject>Leukemia - immunology</subject><subject>Leukemia - pathology</subject><subject>Leukemia, Lymphoid - immunology</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Medical sciences</subject><subject>Original</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rFDEYxkNR2rV66V2Yg_QgTH3fJJOPk7SrtQsLveg5ZDKJxs7HOu-OtP99Z-myrSdPeeH34-EJD2NnCBcIoD9dXQNwqLTEI7ZAKXgJpsJXbAFCQqkB5Al7Q_R7PjhYe8yOFRdWmWrBll9iyiHHflvE-80YifLQF0MqQuuJylVxs74scl_Q0MUieIq0gz5M21i0cbqLXfZv2evkW4rv9u8p-3H99fvyplzfflstL9dlENZsSy9DbaxPVkqpNBeIgTfCNnNH5SulmtDUolbY1KCTNXWSKiBIiVjz2CQtTtnnp9zNVHexCXPp0bduM-bOjw9u8Nn9S_r8y_0c_jpEEJZXfE443yeMw58p0tZ1mUJsW9_HYSKnKwNWav1fESUqA9rM4scnMYwD0RjToQ6C243jnseZ5fcvP3BQ92vM_MOeewq-TaPvQ6aDZqEyFUfxCHuzlTc</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>ELKINS, W. L</creator><creator>PICKARD, A</creator><creator>PIERSON, G. 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R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-a4cb89af9444672311c2d39d3406a566dcdb3b61db07f98bf46c104411b2edf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acute Disease</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - immunology</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Cytotoxicity, Immunologic</topic><topic>Fluorescent Antibody Technique</topic><topic>Hematologic and hematopoietic diseases</topic><topic>HLA Antigens - analysis</topic><topic>Humans</topic><topic>Leukemia - immunology</topic><topic>Leukemia - pathology</topic><topic>Leukemia, Lymphoid - immunology</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Medical sciences</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ELKINS, W. L</creatorcontrib><creatorcontrib>PICKARD, A</creatorcontrib><creatorcontrib>PIERSON, G. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ELKINS, W. L</au><au>PICKARD, A</au><au>PIERSON, G. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deficient expression of class-I HLA in some cases of acute leukemia</atitle><jtitle>Cancer Immunology Immunotherapy</jtitle><addtitle>Cancer Immunol Immunother</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>18</volume><issue>2</issue><spage>91</spage><epage>100</epage><pages>91-100</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><coden>CIIMDN</coden><abstract>Leukemic cells from the blood and marrow of 25 cases of newly diagnosed acute leukemia were presented as target cells to alloreactive effector cells from unrelated normal donors in cell-mediated cytotoxicity assays. In three cases the leukemic targets were poorly killed relative to nonleukemic, HLA-identical target cells. The poor killing of the leukemic cells from one of these cases was shown by competitive inhibition to be due to deficient expression of normal class-I HLA antigens rather than resistance to lysis. Furthermore, the leukemic cells from these three patients were also deficient in binding monoclonal antibodies to nonpolymorphic determinants of class-I HLA and B2 microglobulin. Two additional cases were identified as having a less extensive deficit of HLA, and may be representative of a group with relatively subtle changes in these cell surface antigens. The possible significance of reduced expression of HLA in leukemic progression and in susceptibility to graft-vs-leukemia reactions after bone marrow transplantation is discussed.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>6239685</pmid><doi>10.1007/BF00205741</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0340-7004 |
| ispartof | Cancer Immunology Immunotherapy, 1984-01, Vol.18 (2), p.91-100 |
| issn | 0340-7004 1432-0851 |
| language | eng |
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| source | MEDLINE; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Acute Disease Biological and medical sciences Bone Marrow - immunology Cells, Cultured Child Cytotoxicity, Immunologic Fluorescent Antibody Technique Hematologic and hematopoietic diseases HLA Antigens - analysis Humans Leukemia - immunology Leukemia - pathology Leukemia, Lymphoid - immunology Leukemia, Myeloid, Acute - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Culture Test, Mixed Medical sciences Original |
| title | Deficient expression of class-I HLA in some cases of acute leukemia |
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