Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells
The effect of persistent measles virus infection on the expression of major histocompatibility complex (MHC) class I antigens was studied. Mouse neuroblastoma cells C1300, clone NS20Y, were persistently infected with the Edmonston strain of measles virus. The persistently infected cell line, NS20Y/M...
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| Veröffentlicht in: | Cancer Immunology, Immunotherapy Immunotherapy, 1992-09, Vol.34 (5), p.313-320 |
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| container_title | Cancer Immunology, Immunotherapy |
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| creator | GOPAS, J ITZHAKY, D SEGEV, Y SALZBERG, S TRINK, B ISAKOV, N RAGER-ZISMAN, B |
| description | The effect of persistent measles virus infection on the expression of major histocompatibility complex (MHC) class I antigens was studied. Mouse neuroblastoma cells C1300, clone NS20Y, were persistently infected with the Edmonston strain of measles virus. The persistently infected cell line, NS20Y/MS, expressed augmented levels of both H-2Kk and H-2Dd MHC class I glycoproteins. Activation of two interferon(IFN)-induced enzymes, known to be part of the IFN system: (2'-5')oligoadenylate synthetase and double-stranded-RNA-activated protein kinase, was detected. Measles-virus-infected cells elicited cytotoxic T lymphocytes that recognized and lysed virus-infected and uninfected neuroblastoma cells in an H-2-restricted fashion. Furthermore, immunization of mice with persistently infected cells conferred resistance to tumor growth after challenge with the highly malignant NS20Y cells. The rationale for using measles virus for immunotherapy is that most patients develop lifelong immunity after recovery or vaccination from this infection. Patients developing cancer are likely to have memory cells. A secondary response induced by measles-virus-infected cells may therefore induce an efficient immune response against non-infected tumour cells. |
| doi_str_mv | 10.1007/BF01741552 |
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Mouse neuroblastoma cells C1300, clone NS20Y, were persistently infected with the Edmonston strain of measles virus. The persistently infected cell line, NS20Y/MS, expressed augmented levels of both H-2Kk and H-2Dd MHC class I glycoproteins. Activation of two interferon(IFN)-induced enzymes, known to be part of the IFN system: (2'-5')oligoadenylate synthetase and double-stranded-RNA-activated protein kinase, was detected. Measles-virus-infected cells elicited cytotoxic T lymphocytes that recognized and lysed virus-infected and uninfected neuroblastoma cells in an H-2-restricted fashion. Furthermore, immunization of mice with persistently infected cells conferred resistance to tumor growth after challenge with the highly malignant NS20Y cells. The rationale for using measles virus for immunotherapy is that most patients develop lifelong immunity after recovery or vaccination from this infection. Patients developing cancer are likely to have memory cells. A secondary response induced by measles-virus-infected cells may therefore induce an efficient immune response against non-infected tumour cells.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/BF01741552</identifier><identifier>PMID: 1347254</identifier><identifier>CODEN: CIIMDN</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>2',5'-Oligoadenylate Synthetase - analysis ; Animals ; Antineoplastic agents ; Biological and medical sciences ; Cell Line - drug effects ; eIF-2 Kinase ; Enzyme Activation - drug effects ; Gene Expression ; Histocompatibility Antigens Class I - analysis ; Immunization ; Immunization, Secondary ; Immunotherapy ; Interferon-gamma - pharmacology ; Measles - immunology ; Measles virus - immunology ; Medical sciences ; Mice ; Mice, Inbred Strains ; Mitomycin - pharmacology ; Neoplasm Transplantation ; Neuroblastoma - enzymology ; Neuroblastoma - immunology ; Neuroblastoma - microbiology ; Original ; Pharmacology. Drug treatments ; Protein Kinases - analysis ; T-Lymphocytes, Cytotoxic - immunology</subject><ispartof>Cancer Immunology, Immunotherapy, 1992-09, Vol.34 (5), p.313-320</ispartof><rights>1992 INIST-CNRS</rights><rights>Springer-Verlag 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-d75916d72045df7848143b8601e6236caeed8e14452bdf9cb8452096e9bc68083</citedby><cites>FETCH-LOGICAL-c367t-d75916d72045df7848143b8601e6236caeed8e14452bdf9cb8452096e9bc68083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11038602/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11038602/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5172546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1347254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOPAS, J</creatorcontrib><creatorcontrib>ITZHAKY, D</creatorcontrib><creatorcontrib>SEGEV, Y</creatorcontrib><creatorcontrib>SALZBERG, S</creatorcontrib><creatorcontrib>TRINK, B</creatorcontrib><creatorcontrib>ISAKOV, N</creatorcontrib><creatorcontrib>RAGER-ZISMAN, B</creatorcontrib><title>Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells</title><title>Cancer Immunology, Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><description>The effect of persistent measles virus infection on the expression of major histocompatibility complex (MHC) class I antigens was studied. Mouse neuroblastoma cells C1300, clone NS20Y, were persistently infected with the Edmonston strain of measles virus. The persistently infected cell line, NS20Y/MS, expressed augmented levels of both H-2Kk and H-2Dd MHC class I glycoproteins. Activation of two interferon(IFN)-induced enzymes, known to be part of the IFN system: (2'-5')oligoadenylate synthetase and double-stranded-RNA-activated protein kinase, was detected. Measles-virus-infected cells elicited cytotoxic T lymphocytes that recognized and lysed virus-infected and uninfected neuroblastoma cells in an H-2-restricted fashion. Furthermore, immunization of mice with persistently infected cells conferred resistance to tumor growth after challenge with the highly malignant NS20Y cells. The rationale for using measles virus for immunotherapy is that most patients develop lifelong immunity after recovery or vaccination from this infection. Patients developing cancer are likely to have memory cells. A secondary response induced by measles-virus-infected cells may therefore induce an efficient immune response against non-infected tumour cells.</description><subject>2',5'-Oligoadenylate Synthetase - analysis</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Line - drug effects</subject><subject>eIF-2 Kinase</subject><subject>Enzyme Activation - drug effects</subject><subject>Gene Expression</subject><subject>Histocompatibility Antigens Class I - analysis</subject><subject>Immunization</subject><subject>Immunization, Secondary</subject><subject>Immunotherapy</subject><subject>Interferon-gamma - pharmacology</subject><subject>Measles - immunology</subject><subject>Measles virus - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mitomycin - pharmacology</subject><subject>Neoplasm Transplantation</subject><subject>Neuroblastoma - enzymology</subject><subject>Neuroblastoma - immunology</subject><subject>Neuroblastoma - microbiology</subject><subject>Original</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Kinases - analysis</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUlLBDEQhYMoOi4X70IOnoTWpDu9nUTFDQb0oOcmna52IlmGVPcw_gt_smlGXE6p8L73iqoi5Jizc85YeXF9x3gpeJ6nW2TGRZYmrMr5NpmxTLCkZEzskX3E91ikrK53yS7PRJnmYkY-nyGgxgHcQC1INIB0pcOIVLse1KC9o-AW0qkoWPnuA11E3Ctvl3LQrTZ6-KDTz8CaKiMR6SOF9TIA4mSWrqPa2tH5N3BaTbTvqR2DdkAdjMG30TR4K6kCY_CQ7PTSIBx9vwfk9e725eYhmT_dP95czROVFeWQdGVe86IrUybyri8rUcW526pgHIo0K5QE6CrgQuRp2_W1aqtYsbqAulVFxarsgFxucpdja6FTcQFBmmYZtJXho_FSN_8VpxfNm181nLMs9kljwtkmQQWPGKD_MXPWTHdpfu8S4ZO_7X7RzSGifvqtS1TS9CFuXOMPlvOJKrIvqdGZ1A</recordid><startdate>199209</startdate><enddate>199209</enddate><creator>GOPAS, J</creator><creator>ITZHAKY, D</creator><creator>SEGEV, Y</creator><creator>SALZBERG, S</creator><creator>TRINK, B</creator><creator>ISAKOV, N</creator><creator>RAGER-ZISMAN, B</creator><general>Springer</general><general>Springer-Verlag</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>199209</creationdate><title>Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells</title><author>GOPAS, J ; ITZHAKY, D ; SEGEV, Y ; SALZBERG, S ; TRINK, B ; ISAKOV, N ; RAGER-ZISMAN, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-d75916d72045df7848143b8601e6236caeed8e14452bdf9cb8452096e9bc68083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>2',5'-Oligoadenylate Synthetase - analysis</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cell Line - drug effects</topic><topic>eIF-2 Kinase</topic><topic>Enzyme Activation - drug effects</topic><topic>Gene Expression</topic><topic>Histocompatibility Antigens Class I - analysis</topic><topic>Immunization</topic><topic>Immunization, Secondary</topic><topic>Immunotherapy</topic><topic>Interferon-gamma - pharmacology</topic><topic>Measles - immunology</topic><topic>Measles virus - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mitomycin - pharmacology</topic><topic>Neoplasm Transplantation</topic><topic>Neuroblastoma - enzymology</topic><topic>Neuroblastoma - immunology</topic><topic>Neuroblastoma - microbiology</topic><topic>Original</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Kinases - analysis</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOPAS, J</creatorcontrib><creatorcontrib>ITZHAKY, D</creatorcontrib><creatorcontrib>SEGEV, Y</creatorcontrib><creatorcontrib>SALZBERG, S</creatorcontrib><creatorcontrib>TRINK, B</creatorcontrib><creatorcontrib>ISAKOV, N</creatorcontrib><creatorcontrib>RAGER-ZISMAN, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology, Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOPAS, J</au><au>ITZHAKY, D</au><au>SEGEV, Y</au><au>SALZBERG, S</au><au>TRINK, B</au><au>ISAKOV, N</au><au>RAGER-ZISMAN, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells</atitle><jtitle>Cancer Immunology, Immunotherapy</jtitle><addtitle>Cancer Immunol Immunother</addtitle><date>1992-09</date><risdate>1992</risdate><volume>34</volume><issue>5</issue><spage>313</spage><epage>320</epage><pages>313-320</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><coden>CIIMDN</coden><abstract>The effect of persistent measles virus infection on the expression of major histocompatibility complex (MHC) class I antigens was studied. Mouse neuroblastoma cells C1300, clone NS20Y, were persistently infected with the Edmonston strain of measles virus. The persistently infected cell line, NS20Y/MS, expressed augmented levels of both H-2Kk and H-2Dd MHC class I glycoproteins. Activation of two interferon(IFN)-induced enzymes, known to be part of the IFN system: (2'-5')oligoadenylate synthetase and double-stranded-RNA-activated protein kinase, was detected. Measles-virus-infected cells elicited cytotoxic T lymphocytes that recognized and lysed virus-infected and uninfected neuroblastoma cells in an H-2-restricted fashion. Furthermore, immunization of mice with persistently infected cells conferred resistance to tumor growth after challenge with the highly malignant NS20Y cells. The rationale for using measles virus for immunotherapy is that most patients develop lifelong immunity after recovery or vaccination from this infection. Patients developing cancer are likely to have memory cells. A secondary response induced by measles-virus-infected cells may therefore induce an efficient immune response against non-infected tumour cells.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>1347254</pmid><doi>10.1007/BF01741552</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 2',5'-Oligoadenylate Synthetase - analysis Animals Antineoplastic agents Biological and medical sciences Cell Line - drug effects eIF-2 Kinase Enzyme Activation - drug effects Gene Expression Histocompatibility Antigens Class I - analysis Immunization Immunization, Secondary Immunotherapy Interferon-gamma - pharmacology Measles - immunology Measles virus - immunology Medical sciences Mice Mice, Inbred Strains Mitomycin - pharmacology Neoplasm Transplantation Neuroblastoma - enzymology Neuroblastoma - immunology Neuroblastoma - microbiology Original Pharmacology. Drug treatments Protein Kinases - analysis T-Lymphocytes, Cytotoxic - immunology |
| title | Persistent measles virus infection enhances major histocompatibility complex class I expression and immunogenicity of murine neuroblastoma cells |
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