Carbohydrate-derivatized immunoconjugate of the anti-(carcinoembryonic antigen) monoclonal antibody C46 : immunohistological reactivity and pharmacokinetic comparison with a randomly derivatized C46 immunoconjugate

In this study, a site-specific glycyl-tyrosyl-(N-epsilon-diethylenetriaminepentaacetic acid)-lysine (GYK-DTPA) immunoconjugate of the anti-carcinoembryonic antigen monoclonal antibody C46 (C46-GYK-DTPA) was characterized by immunohistological and immunofluorescence methods for reactivity with normal...

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Veröffentlicht in:	Cancer Immunology Immunotherapy 1990-07, Vol.32 (4), p.207-213
Hauptverfasser:	ROSENSTRAUS, M. J, DAVIS, W. L, LOPES, A. D, D'ALEO, C. J, GILMAN, S. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacokinetics Antibody Specificity Antineoplastic agents Biological and medical sciences Carbohydrates Carcinoembryonic Antigen - immunology Dose-Response Relationship, Immunologic Granulocytes - immunology Humans Immunotherapy Medical sciences Mice Mice, Nude Neoplasm Transplantation Neoplasms - immunology Original Pentetic Acid - chemistry Pharmacology. Drug treatments Tissue Distribution
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