The antileukemic efficacy of an immunotoxin composed of a monoclonal anti-Thy-1 antibody disulfide linked to the ribosome-inactivating protein gelonin

We prepared an immunoconjugate consisting of a monoclonal antibody recognizing the Thy-1 antigen and the ribosome-inactivating protein gelonin linked by a disulfide bond. This immunotoxin preparation was judged to contain less than 5% free antibody or gelonin. It was highly toxic in vitro in an anti...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 1987-07, Vol.25 (1), p.31-40
Hauptverfasser:	Scott, Jr, C F, Goldmacher, V S, Lambert, J M, Chari, R V, Bolender, S, Gauthier, M N, Blättler, W A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Cell Survival Immunotoxins - administration & dosage Isoantibodies - administration & dosage Leukemia, Experimental - therapy Mice Mice, Inbred A Original Plant Proteins - administration & dosage Ribosome Inactivating Proteins, Type 1
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