Deficiency in immunocompetence of mice cured from large MOPC-315 plasmacytomas by melphalan therapy
Mice cured from large MOPC-315 tumors by a single dose of melphalan, 7.5 mg/kg, were examined for up to 60 days after the drug treatment (71 days after the tumor inoculation) for their ability to respond to mitogenic stimulation, specific and nonspecific antigenic stimulation and for their susceptib...
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Veröffentlicht in: | Cancer Immunology Immunotherapy 1989-08, Vol.29 (4), p.279-287 |
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description | Mice cured from large MOPC-315 tumors by a single dose of melphalan, 7.5 mg/kg, were examined for up to 60 days after the drug treatment (71 days after the tumor inoculation) for their ability to respond to mitogenic stimulation, specific and nonspecific antigenic stimulation and for their susceptibility to inoculation with an unrelated tumor, L10 lymphoma. The response of spleen cells from cured mice to mitogenic stimulation by phytohemagglutinin or concanavalin A was slightly depressed at an early stage after the drug treatment. The allogeneic response against C57BL spleen cells and the antibody response against sheep red blood cells (SRBC) of spleen cells from cured mice remained below normal levels during the whole observation period. The deficiency in response to antigenic stimulation was found to be due to impairment in T-cell function. Cured mice were also deficient in their response to SRBC immunization (antibody and delayed-type hypersensitivity responses) and were more susceptible to inoculation with an unrelated tumor, L10 lymphoma, than normal, noninoculated mice. On the other hand, spleen cells of cured mice developed a highly specific cytotoxic response against target MOPC-315 tumor cells and the cured mice were resistant to challenge with an otherwise highly tumorigenic dose of MOPC-315. Thus, cured mice remained deficient for a long period of time in their response to MOPC-315-unrelated antigens but, at the same time, they showed a potent specific antitumor immunity potential in vivo and in vitro. |
doi_str_mv | 10.1007/BF00199216 |
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The response of spleen cells from cured mice to mitogenic stimulation by phytohemagglutinin or concanavalin A was slightly depressed at an early stage after the drug treatment. The allogeneic response against C57BL spleen cells and the antibody response against sheep red blood cells (SRBC) of spleen cells from cured mice remained below normal levels during the whole observation period. The deficiency in response to antigenic stimulation was found to be due to impairment in T-cell function. Cured mice were also deficient in their response to SRBC immunization (antibody and delayed-type hypersensitivity responses) and were more susceptible to inoculation with an unrelated tumor, L10 lymphoma, than normal, noninoculated mice. On the other hand, spleen cells of cured mice developed a highly specific cytotoxic response against target MOPC-315 tumor cells and the cured mice were resistant to challenge with an otherwise highly tumorigenic dose of MOPC-315. Thus, cured mice remained deficient for a long period of time in their response to MOPC-315-unrelated antigens but, at the same time, they showed a potent specific antitumor immunity potential in vivo and in vitro.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/BF00199216</identifier><identifier>PMID: 2787695</identifier><identifier>CODEN: CIIMDN</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antibody Formation ; B-Lymphocytes - immunology ; Biological and medical sciences ; Cytotoxicity, Immunologic ; Dose-Response Relationship, Immunologic ; Host-tumor relations. Immunology. Biological markers ; Hypersensitivity, Delayed - immunology ; Immunity ; Lymphocyte Activation ; Lymphoma - immunology ; Medical sciences ; Melphalan - toxicity ; Mice ; Mitogens - pharmacology ; Original ; Plasmacytoma - drug therapy ; Plasmacytoma - immunology ; Spleen - immunology ; T-Lymphocytes - immunology ; Tumors</subject><ispartof>Cancer Immunology Immunotherapy, 1989-08, Vol.29 (4), p.279-287</ispartof><rights>1991 INIST-CNRS</rights><rights>Springer-Verlag 1989</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-c949c9a0b9b0fb9050daef08c03030b52263f60c6382a6c28a8c2e4622965d073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11038020/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11038020/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19300766$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2787695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHOVAL, S</creatorcontrib><creatorcontrib>OPHIR, R</creatorcontrib><creatorcontrib>SHLOMO BEN-EFRAIM</creatorcontrib><title>Deficiency in immunocompetence of mice cured from large MOPC-315 plasmacytomas by melphalan therapy</title><title>Cancer Immunology Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><description>Mice cured from large MOPC-315 tumors by a single dose of melphalan, 7.5 mg/kg, were examined for up to 60 days after the drug treatment (71 days after the tumor inoculation) for their ability to respond to mitogenic stimulation, specific and nonspecific antigenic stimulation and for their susceptibility to inoculation with an unrelated tumor, L10 lymphoma. The response of spleen cells from cured mice to mitogenic stimulation by phytohemagglutinin or concanavalin A was slightly depressed at an early stage after the drug treatment. The allogeneic response against C57BL spleen cells and the antibody response against sheep red blood cells (SRBC) of spleen cells from cured mice remained below normal levels during the whole observation period. The deficiency in response to antigenic stimulation was found to be due to impairment in T-cell function. Cured mice were also deficient in their response to SRBC immunization (antibody and delayed-type hypersensitivity responses) and were more susceptible to inoculation with an unrelated tumor, L10 lymphoma, than normal, noninoculated mice. On the other hand, spleen cells of cured mice developed a highly specific cytotoxic response against target MOPC-315 tumor cells and the cured mice were resistant to challenge with an otherwise highly tumorigenic dose of MOPC-315. Thus, cured mice remained deficient for a long period of time in their response to MOPC-315-unrelated antigens but, at the same time, they showed a potent specific antitumor immunity potential in vivo and in vitro.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Cytotoxicity, Immunologic</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immunity</subject><subject>Lymphocyte Activation</subject><subject>Lymphoma - immunology</subject><subject>Medical sciences</subject><subject>Melphalan - toxicity</subject><subject>Mice</subject><subject>Mitogens - pharmacology</subject><subject>Original</subject><subject>Plasmacytoma - drug therapy</subject><subject>Plasmacytoma - immunology</subject><subject>Spleen - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumors</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEFr3DAQhUVp2G42vfRe0KWXgpORZMvWqTSbbBJISA7t2YxnpayKZRvJW_C_j8MuScsc3jBv5ht4jH0RcC4AyovLDYAwRgr9gS1FrmQGVSE-siWoHLISIP_ETlP6MzcSjFmwhSyrUptiyejKOk_edjRx33Efwr7rqQ-DHeeZ5b3jwc9K-2i33MU-8Bbjs-UPj0_rTImCDy2mgDSNfcDEm4kH2w47bLHj485GHKYzduKwTfbzUVfs9-b61_o2u3-8uVv_vM8oh3zMyOSGDEJjGnCNgQK2aB1UBGquppBSK6eBtKokapIVViRtrqU0uthCqVbsx4E77Jtgt2S7MWJbD9EHjFPdo6__dzq_q5_7v7UQoCqQMBO-HwgU-5SidW_HAurXqOv3qOflr_--e1s9Zjv7344-JsLWRezIp3eiUTNQa_UCbAqGbw</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>SHOVAL, S</creator><creator>OPHIR, R</creator><creator>SHLOMO BEN-EFRAIM</creator><general>Springer</general><general>Springer-Verlag</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19890801</creationdate><title>Deficiency in immunocompetence of mice cured from large MOPC-315 plasmacytomas by melphalan therapy</title><author>SHOVAL, S ; OPHIR, R ; SHLOMO BEN-EFRAIM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-c949c9a0b9b0fb9050daef08c03030b52263f60c6382a6c28a8c2e4622965d073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Cytotoxicity, Immunologic</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immunity</topic><topic>Lymphocyte Activation</topic><topic>Lymphoma - immunology</topic><topic>Medical sciences</topic><topic>Melphalan - toxicity</topic><topic>Mice</topic><topic>Mitogens - pharmacology</topic><topic>Original</topic><topic>Plasmacytoma - drug therapy</topic><topic>Plasmacytoma - immunology</topic><topic>Spleen - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHOVAL, S</creatorcontrib><creatorcontrib>OPHIR, R</creatorcontrib><creatorcontrib>SHLOMO BEN-EFRAIM</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHOVAL, S</au><au>OPHIR, R</au><au>SHLOMO BEN-EFRAIM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deficiency in immunocompetence of mice cured from large MOPC-315 plasmacytomas by melphalan therapy</atitle><jtitle>Cancer Immunology Immunotherapy</jtitle><addtitle>Cancer Immunol Immunother</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>29</volume><issue>4</issue><spage>279</spage><epage>287</epage><pages>279-287</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><coden>CIIMDN</coden><abstract>Mice cured from large MOPC-315 tumors by a single dose of melphalan, 7.5 mg/kg, were examined for up to 60 days after the drug treatment (71 days after the tumor inoculation) for their ability to respond to mitogenic stimulation, specific and nonspecific antigenic stimulation and for their susceptibility to inoculation with an unrelated tumor, L10 lymphoma. The response of spleen cells from cured mice to mitogenic stimulation by phytohemagglutinin or concanavalin A was slightly depressed at an early stage after the drug treatment. The allogeneic response against C57BL spleen cells and the antibody response against sheep red blood cells (SRBC) of spleen cells from cured mice remained below normal levels during the whole observation period. The deficiency in response to antigenic stimulation was found to be due to impairment in T-cell function. Cured mice were also deficient in their response to SRBC immunization (antibody and delayed-type hypersensitivity responses) and were more susceptible to inoculation with an unrelated tumor, L10 lymphoma, than normal, noninoculated mice. On the other hand, spleen cells of cured mice developed a highly specific cytotoxic response against target MOPC-315 tumor cells and the cured mice were resistant to challenge with an otherwise highly tumorigenic dose of MOPC-315. Thus, cured mice remained deficient for a long period of time in their response to MOPC-315-unrelated antigens but, at the same time, they showed a potent specific antitumor immunity potential in vivo and in vitro.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2787695</pmid><doi>10.1007/BF00199216</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Antibody Formation B-Lymphocytes - immunology Biological and medical sciences Cytotoxicity, Immunologic Dose-Response Relationship, Immunologic Host-tumor relations. Immunology. Biological markers Hypersensitivity, Delayed - immunology Immunity Lymphocyte Activation Lymphoma - immunology Medical sciences Melphalan - toxicity Mice Mitogens - pharmacology Original Plasmacytoma - drug therapy Plasmacytoma - immunology Spleen - immunology T-Lymphocytes - immunology Tumors |
title | Deficiency in immunocompetence of mice cured from large MOPC-315 plasmacytomas by melphalan therapy |
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