Treating tumor-bearing mice with vitamin D3 diminishes tumor-induced myelopoiesis and associated immunosuppression, and reduces tumor metastasis and recurrence

Metastatic Lewis lung carcinoma (LLC-LN7) tumors that secrete granulocyte/macrophage-colony-stimulating factor (GM-CSF) stimulate myelopoiesis and induce bone marrow-derived immunosuppressor cells that are homologous to granulocyte/macrophage progenitor cells. In vitro treatment of the LLC-LN7 cells...

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Veröffentlicht in:	Cancer Immunology Immunotherapy 1995-01, Vol.41 (1), p.37-45
Hauptverfasser:	YOUNG, M. R. I, IHM, J, LOZANO, Y, WRIGHT, M. A, PRECHEL, M. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Carcinoma, Lewis Lung - drug therapy Chemotherapy Cholecalciferol - therapeutic use Female Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Hematopoiesis - drug effects Immunity, Cellular Medical sciences Mice Mice, Inbred C57BL Neoplasm Metastasis Original Pharmacology. Drug treatments T-Lymphocytes - immunology T-Lymphocytes, Regulatory - cytology
Online-Zugang:	Volltext
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