Pim-1 Kinase Protects P-Glycoprotein from Degradation and Enables Its Glycosylation and Cell Surface Expression

The oncogenic serine/threonine kinase Pim-1 phosphorylates and activates the ATP-binding cassette transporter breast cancer resistance protein (ABCG2). The ABC transporter P-glycoprotein (Pgp; ABCB1) also contains a Pim-1 phosphorylation consensus sequence, and we hypothesized that Pim-1 also regula...

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Veröffentlicht in:	Molecular pharmacology 2010-08, Vol.78 (2), p.310-318
Hauptverfasser:	Xie, Yingqiu, Burcu, Mehmet, Linn, Douglas E., Qiu, Yun, Baer, Maria R.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Cell Membrane - metabolism Cycloheximide - pharmacology Flow Cytometry Gene Knockdown Techniques Glycosylation HL-60 Cells Humans Hydrolysis Phosphorylation Proteasome Endopeptidase Complex - metabolism Proto-Oncogene Proteins c-pim-1 - genetics Proto-Oncogene Proteins c-pim-1 - metabolism Ubiquitination
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