Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain

Sphingosine-1-phosphate receptor 1 (S1PR1) is recognized as a novel therapeutic and diagnostic target in neurological disorders. We recently transferred the S1PR1 radioligand [11C]CS1P1 into clinical investigation for multiple sclerosis. Herein, we reported the design, synthesis and evaluation of no...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-04, Vol.66 (7), p.4671-4688
Hauptverfasser:	Qiu, Lin, Jiang, Hao, Zhou, Charles, Wang, Jinzhi, Yu, Yanbo, Zhao, Haiyang, Huang, Tianyu, Gropler, Robert, Perlmutter, Joel S., Benzinger, Tammie L. S., Tu, Zhude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Fluorine Radioisotopes - pharmacokinetics Humans Macaca Positron-Emission Tomography - methods Radiopharmaceuticals - chemistry Sphingosine-1-Phosphate Receptors
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