Natural CD8+ T-cell responses against MHC class I epitopes of the HER-2/neu oncoprotein in patients with epithelial tumors

HER-2/ neu is an immunogenic protein eliciting both humoral and cellular immune responses in patients with HER-2/ neu-positive ((+)) tumors. Preexisting cytotoxic T lymphocyte (CTL) immunity to HER-2/ neu has so far been mainly evaluated in terms of detection of CTL precursor (CTLp) frequencies to t...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2003-12, Vol.52 (12), p.771-779
Hauptverfasser:	SOTIROPOULOU, Panagiota A, PEREZ, Sonia A, VOELTER, Volfgang, ECHNER, Hartmut, MISSITZIS, Ioannis, TSAVARIS, Nick B, PAPAMICHAIL, Michael, BAXEVANIS, Constantin N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Biological and medical sciences CD8-Positive T-Lymphocytes - immunology Cell Division Dendritic Cells - immunology Enzyme-Linked Immunosorbent Assay Epitopes - immunology Female HLA-A2 Antigen - immunology Humans Immunization Immunophenotyping Immunotherapy Interferon-gamma - biosynthesis Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Male Medical sciences Middle Aged Neoplasms - immunology Original Peptide Fragments - immunology Peptide Fragments - metabolism Pharmacology. Drug treatments Receptor, ErbB-2 - immunology T-Lymphocytes, Cytotoxic - immunology
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