A Comprehensive Review on Unveiling the Journey of Digoxin: Past, Present, and Future Perspectives
Digoxin, a cardiac glycoside derived from the foxglove plant ( spp.), has been utilized for centuries in managing various cardiac conditions due to its ability to increase myocardial contractility and regulate heart rate. This comprehensive review explores the historical context, pharmacological pro...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-03, Vol.16 (3), p.e56755-e56755 |
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| creator | Khandelwal, Rahul Vagha, Jayant D Meshram, Revat J Patel, Ankita |
| description | Digoxin, a cardiac glycoside derived from the foxglove plant (
spp.), has been utilized for centuries in managing various cardiac conditions due to its ability to increase myocardial contractility and regulate heart rate. This comprehensive review explores the historical context, pharmacological properties, clinical applications, efficacy, safety profile, challenges, and future perspectives of digoxin. Tracing its journey from traditional medicine to modern cardiovascular therapeutics, we delve into its mechanism of action, therapeutic indications, and clinical guidelines. While digoxin remains a cornerstone therapy for heart failure and atrial fibrillation, its narrow therapeutic index and individual variability in response pose challenges in clinical practice. Nevertheless, ongoing research efforts aim to elucidate its role in emerging therapeutic areas and technological advancements in drug delivery. Despite the advent of newer pharmacological agents, digoxin's enduring relevance lies in its established efficacy, affordability, and global accessibility. This review underscores the symbiotic relationship between tradition and progress in cardiovascular medicine, highlighting the timeless pursuit of medical innovation to optimize patient care. |
| doi_str_mv | 10.7759/cureus.56755 |
| format | Article |
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spp.), has been utilized for centuries in managing various cardiac conditions due to its ability to increase myocardial contractility and regulate heart rate. This comprehensive review explores the historical context, pharmacological properties, clinical applications, efficacy, safety profile, challenges, and future perspectives of digoxin. Tracing its journey from traditional medicine to modern cardiovascular therapeutics, we delve into its mechanism of action, therapeutic indications, and clinical guidelines. While digoxin remains a cornerstone therapy for heart failure and atrial fibrillation, its narrow therapeutic index and individual variability in response pose challenges in clinical practice. Nevertheless, ongoing research efforts aim to elucidate its role in emerging therapeutic areas and technological advancements in drug delivery. 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This review underscores the symbiotic relationship between tradition and progress in cardiovascular medicine, highlighting the timeless pursuit of medical innovation to optimize patient care.</description><subject>18th century</subject><subject>Adenosine triphosphatase</subject><subject>Bioavailability</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Medicine</subject><subject>Mortality</subject><subject>Pediatrics</subject><subject>Pharmacodynamics</subject><subject>Pharmacokinetics</subject><subject>Potassium</subject><subject>Proteins</subject><subject>Sodium</subject><subject>Toxicity</subject><subject>Vomiting</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1PGzEQxa2KqiDKrefKUi8cCB3ba3vNBaFQ-iGkRlU5W44zSYw2drB3Q_nv6xCKoCePPD89vTePkA8MTrWW5rMfMg7lVCot5RtywJlqRy1rm70X8z45KuUWABhoDhrekX3RKglamQMyvaDjtFpnXGIsYYP0F24C3tMU6U3cYOhCXNB-ifRHGnLEB5rm9DIs0p8Qz-jElf6ETjIWjHVwcUavhr5aohPMZY2-r4rlPXk7d13Bo6f3kNxcffk9_ja6_vn1-_jieuQFQD9izDHFQPKaC6fSN1OUxgiGUmHd6KblSnBjPDgu699McOaV5NKbBjXj4pCc73TXw3SFM189ZdfZdQ4rlx9scsG-3sSwtIu0sYyBEEZtFY6fFHK6G7D0dhWKx65zEdNQrIBGMqalaCv66T_0dnugmm9LmRZAPFo62VE-p1Iyzp_dMLDbAu2uQPtYYMU_vkzwDP-rS_wFmsuWfw</recordid><startdate>20240323</startdate><enddate>20240323</enddate><creator>Khandelwal, Rahul</creator><creator>Vagha, Jayant D</creator><creator>Meshram, Revat J</creator><creator>Patel, Ankita</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240323</creationdate><title>A Comprehensive Review on Unveiling the Journey of Digoxin: Past, Present, and Future Perspectives</title><author>Khandelwal, Rahul ; 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spp.), has been utilized for centuries in managing various cardiac conditions due to its ability to increase myocardial contractility and regulate heart rate. This comprehensive review explores the historical context, pharmacological properties, clinical applications, efficacy, safety profile, challenges, and future perspectives of digoxin. Tracing its journey from traditional medicine to modern cardiovascular therapeutics, we delve into its mechanism of action, therapeutic indications, and clinical guidelines. While digoxin remains a cornerstone therapy for heart failure and atrial fibrillation, its narrow therapeutic index and individual variability in response pose challenges in clinical practice. Nevertheless, ongoing research efforts aim to elucidate its role in emerging therapeutic areas and technological advancements in drug delivery. Despite the advent of newer pharmacological agents, digoxin's enduring relevance lies in its established efficacy, affordability, and global accessibility. This review underscores the symbiotic relationship between tradition and progress in cardiovascular medicine, highlighting the timeless pursuit of medical innovation to optimize patient care.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38650769</pmid><doi>10.7759/cureus.56755</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 18th century Adenosine triphosphatase Bioavailability Cardiac arrhythmia Cardiology Drug dosages Enzymes Heart failure Heart rate Medicine Mortality Pediatrics Pharmacodynamics Pharmacokinetics Potassium Proteins Sodium Toxicity Vomiting |
| title | A Comprehensive Review on Unveiling the Journey of Digoxin: Past, Present, and Future Perspectives |
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