The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform

DNA topoisomerase IIα (170 kDa, TOP2α/170) is essential in proliferating cells by resolving DNA topological entanglements during chromosome condensation, replication, and segregation. We previously characterized a C-terminally truncated isoform (TOP2α/90), detectable in human leukemia K562 cells but...

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Veröffentlicht in:	Molecular pharmacology 2018-05, Vol.93 (5), p.515-525
Hauptverfasser:	Kanagasabai, Ragu, Karmahapatra, Soumendrakrishna, Kientz, Corey A., Yu, Yang, Hernandez, Victor A., Kania, Evan E., Yalowich, Jack C., Elton, Terry S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Alkylating - pharmacology Antineoplastic Agents, Alkylating - therapeutic use Cell Line Cell Nucleus - enzymology Dimerization DNA Breaks, Double-Stranded - drug effects DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism Drug Resistance, Neoplasm Etoposide - pharmacology Etoposide - therapeutic use Humans Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism K562 Cells Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology RNA Processing, Post-Transcriptional
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