Entropy Tug-of-War Determines Solvent Effects in the Liquid–Liquid Phase Separation of a Globular Protein

Liquid–liquid phase separation (LLPS) plays a key role in the compartmentalization of cells via the formation of biomolecular condensates. Here, we combined atomistic molecular dynamics (MD) simulations and terahertz (THz) spectroscopy to determine the solvent entropy contribution to the formation o...

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Veröffentlicht in:	The journal of physical chemistry letters 2024-04, Vol.15 (15), p.4047-4055
Hauptverfasser:	Mukherjee, Saumyak, Ramos, Sashary, Pezzotti, Simone, Kalarikkal, Abhishek, Prass, Tobias M., Galazzo, Laura, Gendreizig, Dominik, Barbosa, Natercia, Bordignon, Enrica, Havenith, Martina, Schäfer, Lars V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry Entropy Humans Letter Phase Separation Physical Insights into Chemistry, Catalysis, and Interfaces Solvents Water
Online-Zugang:	Volltext
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