Water-soluble endohedral metallofullerenes: new horizons for biomedical applications
Endohedral metallofullerenes (EMFs) offer a safe avenue to manipulate metals important to biomedical applications such as MRI contrast, X-ray contrast, radiolabeling, radiotherapy, chemotherapy, and the control of inflammation by scavenging reactive oxygen species (ROS). Moreover, functionalizing th...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2023-11, Vol.59 (91), p.13551-13561 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Kopcha, William P Biswas, Rohin Sun, Yue Chueng, Sy-Tsong Dean Dorn, Harry C Zhang, Jianyuan |
| description | Endohedral metallofullerenes (EMFs) offer a safe avenue to manipulate metals important to biomedical applications such as MRI contrast, X-ray contrast, radiolabeling, radiotherapy, chemotherapy, and the control of inflammation by scavenging reactive oxygen species (ROS). Moreover, functionalizing the double bonds on the surface of EMFs modifies their solubility, supramolecular behaviour, binding, targeting characteristics, and physical properties. While most existing water-soluble derivatives possess a statistical mixture of appended functional groups, progress has been made in creating molecularly-precise derivatives with a defined number of surface functional groups, leading to potentially more nuanced control of their behaviour and properties. Further elucidation of the structure-function relationships of these materials is expected to enhance their utility in biomedical applications and possibly broaden their use in diverse areas of science and technology. |
| doi_str_mv | 10.1039/d3cc03603k |
| format | Article |
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Moreover, functionalizing the double bonds on the surface of EMFs modifies their solubility, supramolecular behaviour, binding, targeting characteristics, and physical properties. While most existing water-soluble derivatives possess a statistical mixture of appended functional groups, progress has been made in creating molecularly-precise derivatives with a defined number of surface functional groups, leading to potentially more nuanced control of their behaviour and properties. Further elucidation of the structure-function relationships of these materials is expected to enhance their utility in biomedical applications and possibly broaden their use in diverse areas of science and technology.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>37877250</pmid><doi>10.1039/d3cc03603k</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2919-2734</orcidid><orcidid>https://orcid.org/0000-0002-3150-5314</orcidid></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biomedical materials Fullerenes - chemistry Functional groups Magnetic Resonance Imaging Metallofullerenes Metals - chemistry Physical properties Radiation therapy Radiolabelling Scavenging Solubility Water chemistry |
| title | Water-soluble endohedral metallofullerenes: new horizons for biomedical applications |
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