Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration

Abstract Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a NAD+ hydrolase that plays a key role in axonal degeneration and neuronal cell death. We reported that c-Jun N-terminal kinase (JNK) activates SARM1 through phosphorylation at Ser-548. The importance of SARM1...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2023-11, Vol.174 (6), p.533-548
Hauptverfasser:	Murata, Hitoshi, Phoo, May Tha Zin, Ochi, Toshiki, Tomonobu, Nahoko, Yamamoto, Ken-ichi, Kinoshita, Rie, Miyazaki, Ikuko, Nishibori, Masahiro, Asanuma, Masato, Sakaguchi, Masakiyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Regular Paper
Online-Zugang:	Volltext
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