Anti-renal cell carcinoma chimeric antibody G250: cytokine enhancement of in vitro antibody-dependent cellular cytotoxicity

The chimeric monoclonal antibody cG250 targets the G250 antigen, a transmembrane protein which is expressed on renal carcinoma cells and is identical to the MN/CAIX antigen. In vitro studies have previously demonstrated that cG250 induces antibody-dependent cellular cytotoxicity (ADCC) of G250-posit...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2002-05, Vol.51 (3), p.171-177
Hauptverfasser:	ZHANQI LIU, SMYTH, Fiona E, RENNER, Christoph, LEE, Fook-Thean, OOSTERWIJK, Egbert, SCOTT, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	a-Interferon Animals Antibodies, Monoclonal - therapeutic use Antigens Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - therapy Cell Separation Cytokines Cytokines - metabolism Cytotoxicity Dose-Response Relationship, Drug Flow Cytometry g-Interferon Immunotherapy Immunotherapy - methods Interferon Interferon-gamma - metabolism Interferons - metabolism Interleukin-2 - metabolism Kidney cancer Kidney Neoplasms - immunology Kidney Neoplasms - therapy Killer Cells, Natural - metabolism Medical sciences Mice Monoclonal antibodies Original Pharmacology. Drug treatments Time Factors Tumor Cells, Cultured
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