Reevaluating First-line Therapies in Youth-Onset Type 2 Diabetes

Abstract The prevalence of youth-onset type 2 diabetes is growing worldwide and current first-line treatment with metformin and intensive behavior and lifestyle changes are suboptimal in over 50% of youth within 2 years of diagnosis. This perspective article is a call to action for reevaluation of e...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2024-01, Vol.109 (2), p.e870-e872
Hauptverfasser: Chung, Stephanie T, Davis, Faith, Patel, Tejal, Mabundo, Lilian, Estrada, Doris E
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract The prevalence of youth-onset type 2 diabetes is growing worldwide and current first-line treatment with metformin and intensive behavior and lifestyle changes are suboptimal in over 50% of youth within 2 years of diagnosis. This perspective article is a call to action for reevaluation of existing strategies and critical appraisal of metformin as first-line therapy in youth-onset type 2 diabetes. Increased attention should be given to novel therapeutics approved in youth, including glucagon-like 1 receptor agonists, sodium glucose cotransporter-2, and sociocultural interventions that will promote diabetes self-management.
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgad508