Identification of cells of leukemic stem cell origin with non-canonical regenerative properties

Despite most acute myeloid leukemia (AML) patients entering remission following chemotherapy, outcomes remain poor due to surviving leukemic cells that contribute to relapse. The nature of these enduring cells is poorly understood. Here, through temporal single-cell transcriptomic characterization o...

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Veröffentlicht in:	Cell reports. Medicine 2024-04, Vol.5 (4), p.101485-101485, Article 101485
Hauptverfasser:	Hollands, Cameron G., Boyd, Allison L., Zhao, Xueli, Reid, Jennifer C., Henly, Charisa, ElRafie, Amro, Boylan, David, Broder, Emily, Kalau, Olivia, Johnson, Paige, Mark, Alyssa, McNicol, Jamie, Xenocostas, Anargyros, Berg, Tobias, Foley, Ronan, Trus, Michael, Leber, Brian, Garcia-Horton, Alejandro, Campbell, Clinton, Bhatia, Mickie
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia chemotherapy Gene Expression Profiling Humans injury leukemia stem cells Leukemia, Myeloid, Acute - drug therapy non-canonical regeneration Prognosis Regen71 regeneration enriched cells relapse Stem Cells - metabolism
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