Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy

Despite the immunogenicity of glioblastoma multiforme (GBM), immune-mediated eradication of these tumors remains deficient. Regulatory T cells (Tregs) in the blood and within the tumor microenvironment of GBM patients are known to contribute to their dismal immune responses. Here, we determined whic...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2008-01, Vol.57 (1), p.123-131
Hauptverfasser:	Jordan, Justin T., Sun, Wei, Hussain, S. Farzana, DeAngulo, Guillermo, Prabhu, Sujit S., Heimberger, Amy B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - immunology Cancer Research Carmustine - pharmacology Cell Line, Tumor Cells Chemokine CCL2 - drug effects Chemokine CCL2 - metabolism Chemokine CCL22 - drug effects Chemokine CCL22 - metabolism Chemokines Chemokines - biosynthesis Chemokines - drug effects Chemotaxis, Leukocyte - drug effects Chemotherapy Cytoplasm - chemistry Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Enzyme-Linked Immunosorbent Assay Enzymes Flow Cytometry Glioma - drug therapy Glioma - immunology Humans Immunology Immunotherapy Lymphocytes Medical sciences Medicine Medicine & Public Health Neurology Oncology Original Original Article Pharmacology. Drug treatments Receptors, CCR2 - biosynthesis Receptors, CCR4 - biosynthesis Scandals T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Temozolomide Tumors Tumors of the nervous system. Phacomatoses
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