Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice

Cervical cancer remains a leading cause of cancer-related mortality in women, particularly in developing countries. The causal association between genital human papilloma virus (HPV) infection and cervical cancer has been firmly established, and the oncogenic potential of certain HPV types has been...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2007-07, Vol.56 (7), p.997-1007
Hauptverfasser:	Gomez-Gutierrez, Jorge G, Elpek, Kutlu G, Montes de Oca-Luna, Roberto, Shirwan, Haval, Sam Zhou, H, McMasters, Kelly M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenoviruses Animals Antigen presentation Calreticulin - genetics Cell cycle Cell growth Cell Proliferation Cervical cancer Cervix Female Genes Genetic Vectors - genetics Genetic Vectors - immunology Human papillomavirus Humans Immunology Immunotherapy Interferon-gamma - metabolism Kinases Lymphocytes Medicine Mice Mice, Inbred C57BL Microscopy, Confocal Oncogene Proteins, Viral - genetics Original Papillomavirus Papillomavirus E7 Proteins Papillomavirus Infections - immunology Papillomavirus Infections - prevention & control Papillomavirus Vaccines Peptides Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology T-Lymphocytes - immunology Tumors Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - prevention & control Uterine Cervical Neoplasms - virology Vaccines
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