Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells

An elevated number of Gr-1⁺CD11b⁺ myeloid-derived suppression cells (MDSCs) has been described in mice and human bearing tumor and associated with immune suppression. Arginase I production by MDSCs in the tumor environment may be a central mechanism for immunosuppression and tumor evasion. In this s...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2009-05, Vol.58 (5), p.687-697
Hauptverfasser:	Liu, Yu, Yu, Yinyan, Yang, Suguang, Zeng, Bin, Zhang, Zhuohan, Jiao, Guohui, Zhang, Yuan, Cai, Limin, Yang, Rongcun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antigens, CD - genetics Antigens, CD - physiology Antigens, Surface - analysis Antigens, Surface - genetics Antigens, Surface - physiology Antineoplastic agents Apoptosis Regulatory Proteins - analysis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - physiology Arginase - biosynthesis Arginase - genetics Arginase I Ascites B7-1 Antigen - immunology B7-H1 Antigen Biological and medical sciences Cancer Research Carcinoma - enzymology Carcinoma - immunology Carcinoma - pathology CD11b Antigen - analysis CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor - immunology Cell Line, Tumor - transplantation CTLA-4 CTLA-4 Antigen Cytokines Enzyme Induction Female Immunology Immunotherapy Lymphocytes Male Medical sciences Medicine Medicine & Public Health Membrane Glycoproteins - immunology Mice Mice, Inbred C57BL Myeloid derived suppressor cells Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Oncology Original Original Article Ovarian cancer Ovarian Neoplasms - enzymology Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology PD-1 Peptides - immunology Pharmacology. Drug treatments Programmed Cell Death 1 Receptor Receptors, Chemokine - analysis RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - physiology Specific Pathogen-Free Organisms Spleen Tumors
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