Modified tumour antigen-encoding mRNA facilitates the analysis of naturally occurring and vaccine-induced CD4 and CD8 T cells in cancer patients

The development of effective anti-cancer vaccines requires precise assessment of vaccine-induced immunity. This is often hampered by low ex vivo frequencies of antigen-specific T cells and limited defined epitopes. This study investigates the applicability of modified, in vitro-transcribed mRNA enco...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2009-03, Vol.58 (3), p.325-338
Hauptverfasser:	Knights, Ashley J, Nuber, Natko, Thomson, Christopher W, de la Rosa, Olga, Jäger, Elke, Tiercy, Jean-Marie, van den Broek, Maries, Pascolo, Steve, Knuth, Alexander, Zippelius, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antigens Antigens, Neoplasm - chemistry Antigens, Neoplasm - metabolism Antineoplastic agents Biological and medical sciences Cancer Cancer Research Cancer Vaccines Carcinoma, Non-Small-Cell Lung - metabolism CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cloning Epitopes - chemistry Hospitals Humans Immunology Immunotherapy Interferon-gamma - metabolism Lung Neoplasms - metabolism Lymphocytes Medical sciences Medicine Medicine & Public Health Models, Genetic Neoplasms - blood Neoplasms - metabolism Oncology Original Original Article Peptides Peptides - chemistry Pharmacology. Drug treatments Proteins RNA, Messenger - metabolism T cell receptors Vaccines
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