Cryoimmunotherapy with local co-administration of ex vivo generated dendritic cells and CpG-ODN immune adjuvant, elicits a specific antitumor immunity

Cryoablation is a low-invasive surgical procedure for management of malignant tumors. Tissue destruction is obtained by repeated deep freezing and thawing and results in coagulative necrosis and in apoptosis. This procedure induces the release of tumor-associated antigens and proinflammatory factors...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2014-04, Vol.63 (4), p.369-380
Hauptverfasser:	Alteber, Zoya, Azulay, Meir, Cafri, Gal, Vadai, Ezra, Tzehoval, Esther, Eisenbach, Lea
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Adjuvants, Immunologic - administration & dosage Animals Antigens Cancer Cancer Research Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - secondary Carcinoma, Lewis Lung - surgery Carcinoma, Lewis Lung - therapy CD8-Positive T-Lymphocytes - immunology Cells, Cultured Cloning Combined Modality Therapy CpG Islands Cryosurgery - methods Cytotoxicity Dendritic cells Dendritic Cells - immunology Dendritic Cells - transplantation Foot Immunologic Memory Immunology Immunotherapy - methods Lung Neoplasms - immunology Lung Neoplasms - secondary Lung Neoplasms - surgery Lung Neoplasms - therapy Lymphocytes Male Medicine Medicine & Public Health Melanoma Metastasis Mice Mice, Inbred C57BL Neoplasm Metastasis Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - therapeutic use Oncology Original Original Article Recurrence Signal transduction Specific Pathogen-Free Organisms T-Lymphocyte Subsets - immunology T-Lymphocytes, Cytotoxic - immunology Tumors
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