Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients

Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs against melanoma, called tumor antigen-presenting cells (TAPCells), using a heat...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2012-11, Vol.61 (11), p.2067-2077
Hauptverfasser:	Tittarelli, Andrés, González, Fermín E., Pereda, Cristián, Mora, Gabriela, Muñoz, Leonel, Saffie, Carlos, García, Tamara, Díaz, David, Falcón, Cristián, Hermoso, Marcela, López, Mercedes N., Salazar-Onfray, Flavio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies Antibodies, Neutralizing - immunology Antigen-presenting cells Antigens Antineoplastic agents Biological and medical sciences Cancer Research Cancer therapies Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CC chemokine receptors CCR7 protein CD8 antigen CD8-Positive T-Lymphocytes - immunology CD80 antigen CD83 antigen CD86 antigen Cell activation Cells, Cultured Clinical outcomes Cytokines - biosynthesis Cytokines - immunology Dendritic cells Dendritic Cells - immunology Dentistry Dermatology Differentiation Enzyme-linked immunosorbent assay Female Flow cytometry gamma -Interferon Gene polymorphism Humans Immunology Immunotherapy Interleukins Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Major histocompatibility complex Male Medical sciences Medicine Medicine & Public Health Melanoma Melanoma - immunology Melanoma - mortality Melanoma - pathology Melanoma - therapy Middle Aged Monocytes Monocytes - immunology Oncology Original Original Article Pathogens Pharmacology. Drug treatments Polymerase chain reaction Polymorphism Polymorphism, Genetic Restriction fragment length polymorphism Retrospective Studies Skin Neoplasms - immunology Skin Neoplasms - mortality Skin Neoplasms - pathology Skin Neoplasms - therapy TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Toll-like receptors Treatment Outcome Tumor necrosis factor Tumors of the skin and soft tissue. Premalignant lesions Vaccination Vaccines Young Adult
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