Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer

The programmed death-1 (PD-1) pathway is important in the maintenance of peripheral tolerance and homeostasis through suppression of T cell receptor signaling. As such, it is employed by many tumors as a means of immune escape. We have investigated the role of this pathway in human ovarian cancer (O...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2014-03, Vol.63 (3), p.215-224
Hauptverfasser:	Maine, Christian J., Aziz, Nor Haslinda Abdul, Chatterjee, Jayanta, Hayford, Claudia, Brewig, Nancy, Whilding, Lynsey, George, Andrew J. T., Ghaem-Maghami, Sadaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Blocking - immunology B7-H1 Antigen - genetics B7-H1 Antigen - immunology B7-H1 Antigen - metabolism Biomarkers, Tumor - metabolism Cancer Research Carcinogenesis Cell Line, Tumor Female Gene Expression Regulation, Neoplastic Humans Immunology Immunosuppression Therapy Interleukin-10 - immunology Lymphocyte Activation Medicine Medicine & Public Health Molecular Targeted Therapy - methods Monocytes - immunology Oncology Original Original Article Ovarian cancer Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Prognosis Programmed Cell Death 1 Receptor - metabolism T-Lymphocytes - immunology Tumor Escape
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