An EpCAM/CD3 bispecific antibody efficiently eliminates hepatocellular carcinoma cells with limited galectin-1 expression

There have been several studies suggesting that cancer stem cells (CSCs) contribute to the high rates of recurrence and resistance to therapies observed in hepatocellular carcinoma (HCC). Epithelial cell adhesion molecule (EpCAM) has been demonstrated to be a biomarker of CSCs and a potential therap...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2014-02, Vol.63 (2), p.121-132
Hauptverfasser:	Zhang, Pengfei, Shi, Bizhi, Gao, Huiping, Jiang, Hua, Kong, Juan, Yan, Jin, Pan, Xiaorong, Li, Kesang, Zhang, Pengwei, Yao, Ming, Yang, Shengli, Gu, Jianren, Wang, Hongyang, Li, Zonghai
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Animals Antibodies, Bispecific - therapeutic use Antibodies, Monoclonal - therapeutic use Antigens, CD - analysis Antigens, Neoplasm - analysis Antigens, Neoplasm - immunology Biomarkers Cancer Research Cancer therapies Carcinoma, Hepatocellular - therapy CD3 Complex - immunology Cell adhesion & migration Cell Adhesion Molecules - analysis Cell Adhesion Molecules - immunology Cell Line, Tumor Chemotherapy Cytotoxicity Epithelial Cell Adhesion Molecule Galectin 1 - analysis Galectin 1 - physiology Glycoproteins - analysis Humans Immunology Liver cancer Liver Neoplasms - therapy Lymphocytes Medicine Medicine & Public Health Mice Monoclonal antibodies Oncology Original Original Article Peptides Peptides - analysis Signal transduction Stem cells Tumor necrosis factor-TNF
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