Innate immune sensing of cancer: clues from an identified role for type I IFNs

A subset of patients with a variety of cancers shows evidence of a natural adaptive immune response against their tumor, as evidenced by spontaneous T-cell infiltration, circulating anti-tumor T cells, or antibody responses. Evidence has indicated that such natural immune responses have positive pro...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2012-08, Vol.61 (8), p.1343-1347
Hauptverfasser:	Gajewski, Thomas F., Fuertes, Mercedes B., Woo, Seng-Ryong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigen presentation Antigens Antineoplastic agents Biological and medical sciences Cancer Cancer Research CD8 antigen Congresses as Topic Dendritic cells Dendritic Cells - immunology Focussed Research Review Gene expression Humans Immune response Immunity, Innate - immunology Immunology Immunotherapy Interferon Interferon Type I - immunology Lymphatic system Lymphocytes Lymphocytes T Medical sciences Medicine Medicine & Public Health Melanoma Metastases Mice Neoplasms - immunology Oncology Pharmacology. Drug treatments Signal transduction Signal Transduction - immunology Transcription Tumors
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