Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

Adenosine signaling via the A2a receptor (A2aR) is emerging as an important checkpoint of immune responses. The presence of adenosine in the inflammatory milieu or generated by the CD39/CD73 axis on tissues or T regulatory cells serves to regulate immune responses. By nature of the specialized metab...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2018-08, Vol.67 (8), p.1271-1284
Hauptverfasser:	Leone, Robert D., Sun, Im-Meng, Oh, Min-Hee, Sun, Im-Hong, Wen, Jiayu, Englert, Judson, Powell, Jonathan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine A2 Receptor Antagonists - pharmacology Animal models Animals Antigens, CD - chemistry Antigens, CD - metabolism Cancer Cancer Research CD223 antigen CD4 antigen CD73 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Effector cells Female Foxp3 protein Gene Expression Regulation, Neoplastic Immune checkpoint Immune response Immunological memory Immunology Immunoregulation Immunotherapy Inflammation Lymph nodes Lymphocyte Activation Gene 3 Protein Lymphocytes T Lymphocytes, Tumor-Infiltrating Male Medicine Medicine & Public Health Melanoma, Experimental - drug therapy Melanoma, Experimental - immunology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Oncology Original Original Article PD-1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - metabolism Receptor mechanisms Receptor, Adenosine A2A - chemistry Receptors, Antigen, T-Cell - metabolism T cell receptors T-Lymphocytes, Regulatory - immunology Tumor Cells, Cultured Tumor Microenvironment Xenograft Model Antitumor Assays
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