The multi-receptor inhibitor axitinib reverses tumor-induced immunosuppression and potentiates treatment with immune-modulatory antibodies in preclinical murine models

Cancer immunotherapies have significantly improved the prognosis of cancer patients. Despite the clinical success of targeting inhibitory checkpoint receptors, including PD-1 and/or CTLA-4 on T cells, only a minority of patients derive benefit from these therapies. New strategies to improve cancer i...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2018-05, Vol.67 (5), p.815-824
Hauptverfasser:	Läubli, Heinz, Müller, Philipp, D’Amico, Lucia, Buchi, Mélanie, Kashyap, Abhishek S., Zippelius, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Monoclonal - pharmacology Axitinib Cancer Cancer immunotherapy Cancer Research Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - pathology CD137 antigen CTLA-4 protein Disease Models, Animal Drug Synergism Enzyme inhibitors Hepatitis A Virus Cellular Receptor 2 - antagonists & inhibitors Hepatitis A Virus Cellular Receptor 2 - immunology Imidazoles - pharmacology Immune checkpoint inhibitors Immunology Immunomodulation Immunosuppression Immunosuppression Therapy Immunotherapy Indazoles - pharmacology Inhibitor drugs Lymphocytes T Macrophages Mast cells Medicine Medicine & Public Health Mice Mice, Inbred C57BL Oncology Original Original Article PD-1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase receptors Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Targeted cancer therapy Tumor Cells, Cultured Tumor Necrosis Factor Receptor Superfamily, Member 9 - antagonists & inhibitors Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular endothelial growth factor receptors
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