CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer

Regulatory T cells (Tregs) play a major role in the development of an immunosuppressive tumor microenvironment. Systemic Treg depletion is not favored because of the critical role of Tregs in maintaining immune homeostasis and preventing the autoimmunity. Recently, CCR8 has been identified as an imp...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2020-09, Vol.69 (9), p.1855-1867
Hauptverfasser:	Wang, Tao, Zhou, Quan, Zeng, Han, Zhang, Hongyu, Liu, Zhaopei, Shao, Jialiang, Wang, Zewei, Xiong, Ying, Wang, Jiajun, Bai, Qi, Xia, Yu, Wang, Yiwei, Liu, Li, Zhu, Yu, Xu, Le, Dai, Bo, Guo, Jianming, Chang, Yuan, Wang, Xiang, Xu, Jiejie
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity Bioinformatics Bladder cancer c-Maf protein Cancer Cancer Research CCR8 protein Chemokines Chemotherapy Female Flow cytometry FOXO1 protein Genomes Homeostasis Humans Immune Tolerance - immunology Immunity Immunohistochemistry Immunological tolerance Immunology Immunoregulation Immunosuppression Immunotherapy Immunotherapy - methods Invasiveness Lymphocytes T Male Medicine Medicine & Public Health Molecular modelling Oncology Original Original Article PD-1 protein Phenotypes Prognosis Receptors, CCR8 - immunology Retrospective Studies T-Lymphocytes, Regulatory - immunology Transcription Tumor Microenvironment - immunology Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - therapy
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