Intratumoral injection of hemagglutinating virus of Japan-envelope vector yielded an antitumor effect for advanced melanoma: a phase I/IIa clinical study

Hemagglutinating virus of Japan (HVJ; Sendai virus) is an RNA virus that has cell fusion activity. HVJ-envelope (HVJ-E) is a UV-irradiated HVJ particle that loses viral replication and protein synthesis activity but retains cell fusion activity. We recently reported that HVJ-E has antitumor effects...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2020-06, Vol.69 (6), p.1131-1140
Hauptverfasser:	Kiyohara, Eiji, Tanemura, Atsushi, Nishioka, Megumi, Yamada, Mizuho, Tanaka, Aya, Yokomi, Akinori, Saito, Atsuhiro, Sakura, Kazuma, Nakajima, Toshihiro, Myoui, Akira, Sakurai, Toshiharu, Kawakami, Yutaka, Kaneda, Yasufumi, Katayama, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Cancer Research Cell activation Cell fusion Cell Line, Tumor Clinical Trial Report Cytotoxicity Genetic Vectors - genetics Humans Immunology Injection Injections, Intralesional Lesions Lymphocytes T Medicine Medicine & Public Health Melanoma Melanoma - drug therapy Melanoma - immunology Metastases Natural killer cells Oncology Oncolytic Virotherapy - methods Patients Peripheral blood Protein biosynthesis RNA viruses Skin cancer Tumors Viral Envelope Proteins - genetics γ-Interferon
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