TNFR2+ TILs are significantly associated with improved survival in triple-negative breast cancer patients

In view of the relatively limited efficacy of immunotherapies targeting the PD-1–PD-L1 axis in triple-negative breast cancer (TNBC) and of published reports on tumor-promoting roles of TNFR2+ tumor-infiltrating lymphocytes (TNFR2+ TILs), we determined the incidence of TNFR2+ TILs in TNBC patient tum...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2020-07, Vol.69 (7), p.1315-1326
Hauptverfasser:	Dadiani, Maya, Necula, Daniela, Kahana-Edwin, Smadar, Oren, Nino, Baram, Tamir, Marin, Irina, Morzaev-Sulzbach, Dana, Pavlovski, Anya, Balint-Lahat, Nora, Anafi, Liat, Wiemann, Stefan, Korner, Cindy, Gal-Yam, Einav Nili, Avivi, Camila, Kaufman, Bella, Barshack, Iris, Ben-Baruch, Adit
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Breast cancer Cancer Research Carcinoma, Ductal, Breast - immunology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Cell death Female Follow-Up Studies Humans Immunohistochemistry Immunology Immunotherapy Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Medical prognosis Medicine Medicine & Public Health Middle Aged Oncology Original Original Article PD-1 protein PD-L1 protein Prognosis Receptors, Tumor Necrosis Factor, Type II - metabolism Retrospective Studies Survival Rate Triple Negative Breast Neoplasms - immunology Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology Tumor-infiltrating lymphocytes Tumors
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