Outcomes associated with immune-related adverse events in metastatic non-small cell lung cancer treated with nivolumab: a pooled exploratory analysis from a global cohort

Background Immune-related adverse events (irAEs) comprise a distinct spectrum of auto-inflammatory manifestations triggered due to immune checkpoint inhibitors (ICI). Current data on the association of irAEs with outcomes in NSCLC treated with nivolumab are limited. Methods and objectives We pooled...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2020-07, Vol.69 (7), p.1177-1187
Hauptverfasser:	Naqash, Abdul Rafeh, Ricciuti, Biagio, Owen, Dwight H., Florou, Vaia, Toi, Yukihiro, Cherry, Cynthia, Hafiz, Maida, De Giglio, Andrea, Muzaffar, Mavish, Patel, Sandip H., Sugawara, Shunichi, Burkart, Jarred, Park, Wungki, Chiari, Rita, Sugisaka, Jun, Otterson, Gregory A., de Lima Lopes, Gilberto, Walker, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Immunological - adverse effects Cancer Research Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology Chemotherapy Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - mortality Female Follow-Up Studies Humans Immune checkpoint inhibitors Immunology Immunotherapy Inflammation Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lung Neoplasms - pathology Male Medicine Medicine & Public Health Meta-Analysis as Topic Metastases Metastasis Monoclonal antibodies Multivariate analysis Nivolumab - adverse effects Non-small cell lung carcinoma Oncology Original Original Article Patients Platinum Prognosis Retrospective Studies Small cell lung carcinoma Survival Rate Targeted cancer therapy Withholding Treatment
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