Co-mutations and KRAS G12C inhibitor efficacy in advanced NSCLC

Molecular modifiers of KRAS G12C inhibitor (KRAS G12Ci) efficacy in advanced KRAS G12C -mutant NSCLC are poorly defined. In a large unbiased clinico-genomic analysis of 424 NSCLC patients, we identified and validated co-alterations in KEAP1, SMARCA4 and CDKN2A as major independent determinants of in...

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Veröffentlicht in:	Cancer discovery 2023-07, Vol.13 (7), p.1556-1571
Hauptverfasser:	Negrao, Marcelo V., Araujo, Haniel A., Lamberti, Giuseppe, Cooper, Alissa J., Akhave, Neal S., Zhou, Teng, Delasos, Lukas, Hicks, J. Kevin, Aldea, Mihaela, Minuti, Gabriele, Hines, Jacobi, Aredo, Jacqueline V., Dennis, Michael J., Chakrabarti, Turja, Scott, Susan C., Bironzo, Paolo, Scheffler, Matthias, Christopoulos, Petros, Stenzinger, Albrecht, Riess, Jonathan W., Kim, So Yeon, Goldberg, Sarah B., Li, Mingjia, Wang, Qi, Qing, Yun, Ni, Ying, Do, Minh Truong, Lee, Richard, Ricciuti, Biagio, Alessi, Joao Victor, Wang, Jing, Resuli, Blerina, Landi, Lorenza, Tseng, Shu-Chi, Nishino, Mizuki, Digumarthy, Subba R., Rinsurongkawong, Waree, kawong, Vadeerat Rinsurong, Vaporciyan, Ara A., Blumenschein, George R., Zhang, Jianjun, Owen, Dwight H., Blakely, Collin M., Mountzios, Giannis, Shu, Catherine A., Bestvina, Christine M., Garassino, Marina Chiara, Marrone, Kristen A., Gray, Jhanelle E., Patel, Sandip Pravin, Cummings, Amy L., Wakelee, Heather A., Wolf, Juergen, Scagliotti, Giorgio Vittorio, Cappuzzo, Federico, Barlesi, Fabrice, Patil, Pradnya D., Drusbosky, Leylah, Gibbons, Don L., Meric-Bernstam, Funda, Lee, J. Jack, Heymach, John V., Hong, David S., Heist, Rebecca S., Awad, Mark M., Skoulidis, Ferdinandos
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Sprache:	eng
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