TMBstable: a variant caller controls performance variation across heterogeneous sequencing samples

In cancer genomics, variant calling has advanced, but traditional mean accuracy evaluations are inadequate for biomarkers like tumor mutation burden, which vary significantly across samples, affecting immunotherapy patient selection and threshold settings. In this study, we introduce TMBstable, an i...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Briefings in bioinformatics 2024-03, Vol.25 (3)
Hauptverfasser:	Wang, Shenjie, Zhu, Xiaoyan, Wang, Xuwen, Liu, Yuqian, Zhao, Minchao, Chang, Zhili, Wang, Xiaonan, Shao, Yang, Wang, Jiayin
Format:	Artikel
Sprache:	eng
Schlagworte:	Problem Solving Protocol
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!