Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs

Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes for determination of a drug's pharmacokinetic parameters, which have direct impacts on efficacy and adverse drug reactions (ADRs). The chemical structures, dosage forms, and sites and routes of administrat...

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Veröffentlicht in:	Drug metabolism and disposition 2022-06, Vol.50 (6), p.888-897
Hauptverfasser:	Migliorati, Julia M, Liu, Sunna, Liu, Anna, Gogate, Anagha, Nair, Sreenidhi, Bahal, Raman, Rasmussen, Theodore P, Manautou, José E, Zhong, Xiao-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products Drug-Related Side Effects and Adverse Reactions - genetics Exons Humans Oligonucleotides Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - therapeutic use Special Section on Pharmacokinetics and ADME of Biological Therapeutics United States United States Food and Drug Administration
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