Coupling and regulation mechanisms of the flavin-dependent halogenase PyrH observed by infrared difference spectroscopy

Flavin-dependent halogenases are central enzymes in the production of halogenated secondary metabolites in various organisms and they constitute highly promising biocatalysts for regioselective halogenation. The mechanism of these monooxygenases includes formation of hypohalous acid from a reaction...

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Veröffentlicht in:	The Journal of biological chemistry 2024-04, Vol.300 (4), p.107210-107210, Article 107210
Hauptverfasser:	Schroeder, Lea, Diepold, Niklas, Gäfe, Simon, Niemann, Hartmut H., Kottke, Tilman
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric regulation bacterial metabolism enzyme mechanism flavin adenine dinucleotide (FAD) flavoprotein fourier transform IR (FTIR) halogenase monooxygenase protein conformation tryptophan
Online-Zugang:	Volltext
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