Silica nanoparticles alleviate the immunosuppression, oxidative stress, biochemical, behavioral, and histopathological alterations induced by Aeromonas veronii infection in African catfish (Clarias gariepinus)
In the aquaculture industry, silica nanoparticles (SiNPs) have great significance, mainly for confronting diseases. Therefore, the present study aims to assess the antibacterial efficiency of SiNPs as a versatile trial against Aeromonas veronii infection in African catfish ( Clarias gariepinus ). Fu...
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| Veröffentlicht in: | Fish physiology and biochemistry 2024-04, Vol.50 (2), p.767-783 |
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| creator | Mahboub, Heba H. Gad, Wafaa M. Aziz, Enas K. Nasr, Mona Abdelghany Fahmy, Esraa M. Mansour, Dina Mohamed Rasheed, Nesma Ali, Hanaa S. Ismail, Sameh H. Abdel Rahman, Afaf N. |
| description | In the aquaculture industry, silica nanoparticles (SiNPs) have great significance, mainly for confronting diseases. Therefore, the present study aims to assess the antibacterial efficiency of SiNPs as a versatile trial against
Aeromonas veronii
infection in African catfish (
Clarias gariepinus
). Further, we investigated the influence of SiNPs in palliating the immune-antioxidant stress biochemical, ethological, and histopathological alterations induced by
A. veronii
. The experiment was conducted for 10 days, and about 120 fish were distributed into four groups at random, with 30 fish each. The first group is a control that was neither exposed to infection nor SiNPs. The second group (SiNPs) was vulnerable to SiNPs at a concentration of 20 mg/L in water. The third group was experimentally infected with
A. veronii
at a concentration of 1.5 × 10
7
CFU/mL. The fourth group (
A. veronii +
SiNPs) was exposed to SiNPs and infected with
A. veronii
. Results outlined that
A. veronii
infection induced behavioral alterations and suppression of immune-antioxidant responses that appeared as a clear decline in protein profile indices, complement 3, lysozyme activity, glutathione peroxidase, and total antioxidant capacity. The kidney and liver function biomarkers (creatinine, urea, alkaline phosphatase, and alanine aminotransferase) and lipid peroxide (malondialdehyde) were substantially increased in the
A. veronii
group, with marked histopathological changes and immunohistochemical alterations in these tissues. Interestingly, the exposure to SiNPs resulted in a clear improvement in all measured biomarkers and a noticeable regeneration of the histopathological changes. Overall, it will establish that SiNPs are a new, successful tool for opposing immunological, antioxidant, physiological, and histopathological alterations induced by
A. veronii
infection. |
| doi_str_mv | 10.1007/s10695-023-01274-6 |
| format | Article |
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Aeromonas veronii
infection in African catfish (
Clarias gariepinus
). Further, we investigated the influence of SiNPs in palliating the immune-antioxidant stress biochemical, ethological, and histopathological alterations induced by
A. veronii
. The experiment was conducted for 10 days, and about 120 fish were distributed into four groups at random, with 30 fish each. The first group is a control that was neither exposed to infection nor SiNPs. The second group (SiNPs) was vulnerable to SiNPs at a concentration of 20 mg/L in water. The third group was experimentally infected with
A. veronii
at a concentration of 1.5 × 10
7
CFU/mL. The fourth group (
A. veronii +
SiNPs) was exposed to SiNPs and infected with
A. veronii
. Results outlined that
A. veronii
infection induced behavioral alterations and suppression of immune-antioxidant responses that appeared as a clear decline in protein profile indices, complement 3, lysozyme activity, glutathione peroxidase, and total antioxidant capacity. The kidney and liver function biomarkers (creatinine, urea, alkaline phosphatase, and alanine aminotransferase) and lipid peroxide (malondialdehyde) were substantially increased in the
A. veronii
group, with marked histopathological changes and immunohistochemical alterations in these tissues. Interestingly, the exposure to SiNPs resulted in a clear improvement in all measured biomarkers and a noticeable regeneration of the histopathological changes. Overall, it will establish that SiNPs are a new, successful tool for opposing immunological, antioxidant, physiological, and histopathological alterations induced by
A. veronii
infection.</description><identifier>ISSN: 0920-1742</identifier><identifier>EISSN: 1573-5168</identifier><identifier>DOI: 10.1007/s10695-023-01274-6</identifier><identifier>PMID: 38060081</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aeromonas veronii ; Alanine ; Alanine transaminase ; Alkaline phosphatase ; Animal Anatomy ; Animal Biochemistry ; Animal Physiology ; Antibiotics ; antioxidant activity ; Antioxidants ; Aquaculture ; aquaculture industry ; Biological stress ; Biomarkers ; Biomedical and Life Sciences ; Catfish ; Clarias gariepinus ; complement ; Creatinine ; Exposure ; Fish ; Freshwater & Marine Ecology ; Glutathione ; Glutathione peroxidase ; Histology ; Histopathology ; immunohistochemistry ; Immunology ; Immunosuppression ; Infections ; kidneys ; Life Sciences ; lipid peroxides ; Lipids ; liver function ; Lysozyme ; Malondialdehyde ; Morphology ; Nanoparticles ; Oxidative stress ; Peroxidase ; Phosphatase ; Polyculture (aquaculture) ; protein composition ; Regeneration (biological) ; Silica ; Silicon dioxide ; Urea ; Whitefish ; Zoology</subject><ispartof>Fish physiology and biochemistry, 2024-04, Vol.50 (2), p.767-783</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-57615c6777f127a838eae841078229b883b6ad1855c568dde86c450ba0aafc03</citedby><cites>FETCH-LOGICAL-c508t-57615c6777f127a838eae841078229b883b6ad1855c568dde86c450ba0aafc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10695-023-01274-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10695-023-01274-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38060081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahboub, Heba H.</creatorcontrib><creatorcontrib>Gad, Wafaa M.</creatorcontrib><creatorcontrib>Aziz, Enas K.</creatorcontrib><creatorcontrib>Nasr, Mona Abdelghany</creatorcontrib><creatorcontrib>Fahmy, Esraa M.</creatorcontrib><creatorcontrib>Mansour, Dina Mohamed</creatorcontrib><creatorcontrib>Rasheed, Nesma</creatorcontrib><creatorcontrib>Ali, Hanaa S.</creatorcontrib><creatorcontrib>Ismail, Sameh H.</creatorcontrib><creatorcontrib>Abdel Rahman, Afaf N.</creatorcontrib><title>Silica nanoparticles alleviate the immunosuppression, oxidative stress, biochemical, behavioral, and histopathological alterations induced by Aeromonas veronii infection in African catfish (Clarias gariepinus)</title><title>Fish physiology and biochemistry</title><addtitle>Fish Physiol Biochem</addtitle><addtitle>Fish Physiol Biochem</addtitle><description>In the aquaculture industry, silica nanoparticles (SiNPs) have great significance, mainly for confronting diseases. Therefore, the present study aims to assess the antibacterial efficiency of SiNPs as a versatile trial against
Aeromonas veronii
infection in African catfish (
Clarias gariepinus
). Further, we investigated the influence of SiNPs in palliating the immune-antioxidant stress biochemical, ethological, and histopathological alterations induced by
A. veronii
. The experiment was conducted for 10 days, and about 120 fish were distributed into four groups at random, with 30 fish each. The first group is a control that was neither exposed to infection nor SiNPs. The second group (SiNPs) was vulnerable to SiNPs at a concentration of 20 mg/L in water. The third group was experimentally infected with
A. veronii
at a concentration of 1.5 × 10
7
CFU/mL. The fourth group (
A. veronii +
SiNPs) was exposed to SiNPs and infected with
A. veronii
. Results outlined that
A. veronii
infection induced behavioral alterations and suppression of immune-antioxidant responses that appeared as a clear decline in protein profile indices, complement 3, lysozyme activity, glutathione peroxidase, and total antioxidant capacity. The kidney and liver function biomarkers (creatinine, urea, alkaline phosphatase, and alanine aminotransferase) and lipid peroxide (malondialdehyde) were substantially increased in the
A. veronii
group, with marked histopathological changes and immunohistochemical alterations in these tissues. Interestingly, the exposure to SiNPs resulted in a clear improvement in all measured biomarkers and a noticeable regeneration of the histopathological changes. Overall, it will establish that SiNPs are a new, successful tool for opposing immunological, antioxidant, physiological, and histopathological alterations induced by
A. veronii
infection.</description><subject>Aeromonas veronii</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animal Physiology</subject><subject>Antibiotics</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Aquaculture</subject><subject>aquaculture industry</subject><subject>Biological stress</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Catfish</subject><subject>Clarias gariepinus</subject><subject>complement</subject><subject>Creatinine</subject><subject>Exposure</subject><subject>Fish</subject><subject>Freshwater & Marine Ecology</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Histology</subject><subject>Histopathology</subject><subject>immunohistochemistry</subject><subject>Immunology</subject><subject>Immunosuppression</subject><subject>Infections</subject><subject>kidneys</subject><subject>Life Sciences</subject><subject>lipid peroxides</subject><subject>Lipids</subject><subject>liver function</subject><subject>Lysozyme</subject><subject>Malondialdehyde</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Phosphatase</subject><subject>Polyculture (aquaculture)</subject><subject>protein composition</subject><subject>Regeneration (biological)</subject><subject>Silica</subject><subject>Silicon 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H.</creator><creator>Gad, Wafaa M.</creator><creator>Aziz, Enas K.</creator><creator>Nasr, Mona Abdelghany</creator><creator>Fahmy, Esraa M.</creator><creator>Mansour, Dina Mohamed</creator><creator>Rasheed, Nesma</creator><creator>Ali, Hanaa S.</creator><creator>Ismail, Sameh H.</creator><creator>Abdel Rahman, Afaf N.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20240401</creationdate><title>Silica nanoparticles alleviate the immunosuppression, oxidative stress, biochemical, behavioral, and histopathological alterations induced by Aeromonas veronii infection in African catfish (Clarias gariepinus)</title><author>Mahboub, Heba H. ; Gad, Wafaa M. ; Aziz, Enas K. ; Nasr, Mona Abdelghany ; Fahmy, Esraa M. ; Mansour, Dina Mohamed ; Rasheed, Nesma ; Ali, Hanaa S. ; Ismail, Sameh H. ; Abdel Rahman, Afaf N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-57615c6777f127a838eae841078229b883b6ad1855c568dde86c450ba0aafc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aeromonas veronii</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alkaline phosphatase</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animal Physiology</topic><topic>Antibiotics</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Aquaculture</topic><topic>aquaculture industry</topic><topic>Biological stress</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Catfish</topic><topic>Clarias gariepinus</topic><topic>complement</topic><topic>Creatinine</topic><topic>Exposure</topic><topic>Fish</topic><topic>Freshwater & Marine Ecology</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Histology</topic><topic>Histopathology</topic><topic>immunohistochemistry</topic><topic>Immunology</topic><topic>Immunosuppression</topic><topic>Infections</topic><topic>kidneys</topic><topic>Life Sciences</topic><topic>lipid peroxides</topic><topic>Lipids</topic><topic>liver function</topic><topic>Lysozyme</topic><topic>Malondialdehyde</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><topic>Phosphatase</topic><topic>Polyculture (aquaculture)</topic><topic>protein composition</topic><topic>Regeneration (biological)</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>Urea</topic><topic>Whitefish</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahboub, Heba H.</creatorcontrib><creatorcontrib>Gad, Wafaa M.</creatorcontrib><creatorcontrib>Aziz, Enas K.</creatorcontrib><creatorcontrib>Nasr, Mona Abdelghany</creatorcontrib><creatorcontrib>Fahmy, Esraa M.</creatorcontrib><creatorcontrib>Mansour, Dina Mohamed</creatorcontrib><creatorcontrib>Rasheed, Nesma</creatorcontrib><creatorcontrib>Ali, Hanaa S.</creatorcontrib><creatorcontrib>Ismail, Sameh H.</creatorcontrib><creatorcontrib>Abdel Rahman, Afaf N.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception 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catfish (Clarias gariepinus)</atitle><jtitle>Fish physiology and biochemistry</jtitle><stitle>Fish Physiol Biochem</stitle><addtitle>Fish Physiol Biochem</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>50</volume><issue>2</issue><spage>767</spage><epage>783</epage><pages>767-783</pages><issn>0920-1742</issn><eissn>1573-5168</eissn><abstract>In the aquaculture industry, silica nanoparticles (SiNPs) have great significance, mainly for confronting diseases. Therefore, the present study aims to assess the antibacterial efficiency of SiNPs as a versatile trial against
Aeromonas veronii
infection in African catfish (
Clarias gariepinus
). Further, we investigated the influence of SiNPs in palliating the immune-antioxidant stress biochemical, ethological, and histopathological alterations induced by
A. veronii
. The experiment was conducted for 10 days, and about 120 fish were distributed into four groups at random, with 30 fish each. The first group is a control that was neither exposed to infection nor SiNPs. The second group (SiNPs) was vulnerable to SiNPs at a concentration of 20 mg/L in water. The third group was experimentally infected with
A. veronii
at a concentration of 1.5 × 10
7
CFU/mL. The fourth group (
A. veronii +
SiNPs) was exposed to SiNPs and infected with
A. veronii
. Results outlined that
A. veronii
infection induced behavioral alterations and suppression of immune-antioxidant responses that appeared as a clear decline in protein profile indices, complement 3, lysozyme activity, glutathione peroxidase, and total antioxidant capacity. The kidney and liver function biomarkers (creatinine, urea, alkaline phosphatase, and alanine aminotransferase) and lipid peroxide (malondialdehyde) were substantially increased in the
A. veronii
group, with marked histopathological changes and immunohistochemical alterations in these tissues. Interestingly, the exposure to SiNPs resulted in a clear improvement in all measured biomarkers and a noticeable regeneration of the histopathological changes. Overall, it will establish that SiNPs are a new, successful tool for opposing immunological, antioxidant, physiological, and histopathological alterations induced by
A. veronii
infection.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>38060081</pmid><doi>10.1007/s10695-023-01274-6</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-1742 |
| ispartof | Fish physiology and biochemistry, 2024-04, Vol.50 (2), p.767-783 |
| issn | 0920-1742 1573-5168 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11021351 |
| source | SpringerLink Journals |
| subjects | Aeromonas veronii Alanine Alanine transaminase Alkaline phosphatase Animal Anatomy Animal Biochemistry Animal Physiology Antibiotics antioxidant activity Antioxidants Aquaculture aquaculture industry Biological stress Biomarkers Biomedical and Life Sciences Catfish Clarias gariepinus complement Creatinine Exposure Fish Freshwater & Marine Ecology Glutathione Glutathione peroxidase Histology Histopathology immunohistochemistry Immunology Immunosuppression Infections kidneys Life Sciences lipid peroxides Lipids liver function Lysozyme Malondialdehyde Morphology Nanoparticles Oxidative stress Peroxidase Phosphatase Polyculture (aquaculture) protein composition Regeneration (biological) Silica Silicon dioxide Urea Whitefish Zoology |
| title | Silica nanoparticles alleviate the immunosuppression, oxidative stress, biochemical, behavioral, and histopathological alterations induced by Aeromonas veronii infection in African catfish (Clarias gariepinus) |
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