Ca2+ Depletion in the ER Causes Store-Operated Ca2+ Entry via the TRPC6 Channel in Mouse Brown Adipocytes

beta3-adrenergic activation causes Ca2+ release from the mitochondria and subsequent Ca2+ release from the endoplasmic reticulum (ER), evoking store-operated Ca2+ entry (SOCE) due to Ca2+ depletion from the ER in mouse brown adipocytes. In this study, we investigated how Ca2+ depletion from the ER e...

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Veröffentlicht in:	Physiological research 2024-03, Vol.73 (1), p.69-80
Hauptverfasser:	Hayato, R, Matsumoto, T, Higure, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes, Brown - metabolism Adipose tissue Adrenergic receptors Animals Ca2+-transporting ATPase Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium influx Calcium Signaling Cyclopiazonic acid Dehydrogenases Endoplasmic reticulum Endoplasmic Reticulum - metabolism Fluorometry Homeostasis Kinases Metabolic syndrome Mice Mitochondria Photonics Physiology Protein turnover Proteins Thermogenesis Transient Receptor Potential Channels - metabolism Transient receptor potential proteins Triglycerides TRPC Cation Channels - metabolism TRPC6 Cation Channel - metabolism Uncoupling protein 1
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