ctDNA transiting into urine is ultrashort and facilitates noninvasive liquid biopsy of HPV+ oropharyngeal cancer

BACKGROUNDTransrenal cell-free tumor DNA (TR-ctDNA), which transits from the bloodstream into urine, has the potential to enable noninvasive cancer detection for a wide variety of nonurologic cancer types.MethodsUsing whole-genome sequencing, we discovered that urine TR-ctDNA fragments across multip...

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Veröffentlicht in:	JCI insight 2024-02, Vol.9 (6)
Hauptverfasser:	Bhambhani, Chandan, Kang, Qing, Hovelson, Daniel H, Sandford, Erin, Olesnavich, Mary, Dermody, Sarah M, Wolfgang, Jenny, Tuck, Kirsten L, Brummel, Collin, Bhangale, Apurva D, He, Kuang, Gutierrez, Marc G, Lindstrom, Ryan H, Liu, Chia-Jen, Tuck, Melissa, Kandarpa, Malathi, Mierzwa, Michelle, Casper, Keith, Prince, Mark E, Krauss, John C, Talpaz, Moshe, Henry, N Lynn, Giraldez, Maria D, Ramnath, Nithya, Tomlins, Scott A, Swiecicki, Paul L, Brenner, J Chad, Tewari, Muneesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Clinical Medicine DNA, Neoplasm Head and Neck Neoplasms Humans Liquid Biopsy Oropharyngeal Neoplasms - diagnosis Oropharyngeal Neoplasms - genetics Papillomavirus Infections - genetics Squamous Cell Carcinoma of Head and Neck United States
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Zusammenfassung:	BACKGROUNDTransrenal cell-free tumor DNA (TR-ctDNA), which transits from the bloodstream into urine, has the potential to enable noninvasive cancer detection for a wide variety of nonurologic cancer types.MethodsUsing whole-genome sequencing, we discovered that urine TR-ctDNA fragments across multiple cancer types are predominantly ultrashort (
ISSN:	2379-3708 2379-3708
DOI:	10.1172/jci.insight.177759