Carpesii fructus extract exhibits neuroprotective effects in cellular and Caenorhabditis elegans models of Parkinson's disease

Objective Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Despite extensive research, no definitive cure or effective disease‐modifying treatment for PD exists to date. Therefore, the id...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2024-04, Vol.30 (4), p.e14515-n/a
Hauptverfasser:	Zhu, Feng‐Dan, Wang, Bin‐Ding, Qin, Da‐Lian, Su, Xiao‐Hui, Yu, Lu, Wu, Jian‐Ming, Law, Betty Yuen‐Kwan, Guo, Min‐Song, Yu, Chong‐Lin, Zhou, Xiao‐Gang, Wu, An‐Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	6‐OHDA Aging alpha-Synuclein - metabolism Animals Antibodies Apoptosis Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Carpesii fructus extract Cell viability Disease Models, Animal Dopamine receptors Dopaminergic Neurons - metabolism Hydrogen peroxide Hydrogen Peroxide - metabolism Hydrogen Peroxide - toxicity Life span MAP kinase MAPK pathway Membrane potential Mitochondria Movement disorders Natural products Nematodes Neurodegeneration Neurodegenerative diseases Neuromodulation Neurons Neuroprotection Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotoxicity Original Oxidative stress Oxidopamine - toxicity Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Pathogenesis PC‐12 cells Penicillin Phenotypes Plasmids Proteins Reactive oxygen species Reactive Oxygen Species - metabolism RNA-mediated interference Signal transduction Solvents Substantia nigra Synuclein Western blotting α‐Synuclein
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