Multiparametric hippocampal signatures for early diagnosis of Alzheimer's disease using 18F‐FDG PET/MRI Radiomics

Purpose This study aimed to explore the utility of hippocampal radiomics using multiparametric simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) for early diagnosis of Alzheimer's disease (AD). Methods A total of 53 healthy control (HC) participants, 55 patients with amnestic mild cognitive impairment (aMCI), and 51 patients with AD were included in this study. All participants accepted simultaneous PET/MRI scans, including 18F‐fluorodeoxyglucose (18F‐FDG) PET, 3D arterial spin labeling (ASL), and high‐resolution T1‐weighted imaging (3D T1WI). Radiomics features were extracted from the hippocampus region on those three modal images. Logistic regression models were trained to classify AD and HC, AD and aMCI, aMCI and HC respectively. The diagnostic performance and radiomics score (Rad‐Score) of logistic regression models were evaluated from 5‐fold cross‐validation. Results The hippocampal radiomics features demonstrated favorable diagnostic performance, with the multimodal classifier outperforming the single‐modal classifier in the binary classification of HC, aMCI, and AD. Using the multimodal classifier, we achieved an area under the receiver operating characteristic curve (AUC) of 0.98 and accuracy of 96.7% for classifying AD from HC, and an AUC of 0.86 and accuracy of 80.6% for classifying aMCI from HC. The value of Rad‐Score differed significantly between the AD and HC (p