Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors

Tumor-targeted near-infrared fluorescent dyes have the potential to improve cancer surgery by enabling surgeons to locate and resect more malignant lesions where good visualization tools are required to ensure complete removal of malignant tissue. Although the tumor-targeted fluorescent dyes used in...

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Veröffentlicht in:	Bioconjugate chemistry 2017-11, Vol.28 (11), p.2865-2873
Hauptverfasser:	Mahalingam, Sakkarapalayam M, Dudkin, Vadim Y, Goldberg, Shalom, Klein, Donna, Yi, Fang, Singhal, Sunil, O’Neil, Karyn T, Low, Philip S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animal tissues Animals Antibodies Antigen (tumor-associated) Antigens Cancer Cell Line, Tumor Color removal Dyes Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - analysis ErbB Receptors - metabolism Fluorescence Fluorescent dyes Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Fluorescent indicators Humans I.R. radiation Infrared Rays Lesions Low molecular weights Medical personnel Mice Mice, Nude Models, Molecular Molecular weight Molecules Near infrared radiation Neoplasms - diagnostic imaging Neoplasms - metabolism Neoplasms - surgery Optical Imaging - methods Optimization Organic chemistry Proteins - chemistry Proteins - metabolism Rodents Scaffolds Solid tumors Surgery Surgical instruments Tumors Xenografts
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