Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease
Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of photoreceptors as treatment for these conditions are underway. In this review, we summarize recent progress in the field of ph...
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| Veröffentlicht in: | Stem cells translational medicine 2024-04, Vol.13 (4), p.332-345 |
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| creator | Klymenko, Valeriia González Martínez, Orlando G Zarbin, Marco A |
| description | Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of photoreceptors as treatment for these conditions are underway. In this review, we summarize recent progress in the field of photoreceptor transplantation, including some pertinent results regarding photoreceptor manufacture, photoreceptor transplantation, mechanisms of donor-host cell integration such as material transfer and photoreceptor transplant immunology. We conclude by proposing several approaches that may provide a rational basis for selecting a vision restoration strategy (eg, donor-host synapse formation vs donor-host nanotube formation) and improved transplant efficiency. |
| doi_str_mv | 10.1093/stcltm/szae005 |
| format | Article |
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| source | MEDLINE; Oxford Journals Open Access Collection; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cell- and Tissue-Based Therapy Concise Reviews Humans Macular Degeneration - therapy Photoreceptor Cells Retina Retinal Degeneration - therapy Stem Cell Transplantation - methods |
| title | Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease |
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